MYL3/CMLC1 anticorps

N° du produit ABIN969303

Détail du produit anti-MYL3/CMLC1 anticorps

Antigène: MYL3/CMLC1 (MYL3) (Myosin, Light Chain 3 (MYL3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MYL3/CMLC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of MYL3 expressed in E. coli.

Clone: 3F8

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-MYL3/CMLC1 (ABIN969303)

Haase, Dobbernack, Tünnemann, Karczewski, Cardoso, Petzhold, Schlegel, Lutter, Pierschalek, Behlke, Morano: "Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 7, pp. 865-73, (2006) (PubMed).

Xie, Huang, Huang, Zhou, Gong: "The functional domains of human ventricular myosin light chain 1." dans: Biophysical chemistry, Vol. 106, Issue 1, pp. 57-66, (2003) (PubMed).

Détails sur MYL3/CMLC1

Antigène: MYL3/CMLC1 (MYL3) (Myosin, Light Chain 3 (MYL3))

Autre désignation: MYL3 (MYL3 Produits)

Synonymes: anticorps CMD1S, anticorps CMH1, anticorps MPD1, anticorps MYHCB, anticorps SPMD, anticorps SPMM, anticorps B-MHC, anticorps MyHC-I, anticorps Myhc-b, anticorps Myhcb, anticorps beta-MHC, anticorps MLC1s, anticorps MLC1v, anticorps Mylc, anticorps VLC1, anticorps Mylc1v, anticorps CMH8, anticorps MLC1SB, anticorps MLC1V, anticorps mlc1v, anticorps myl3-a, anticorps myl3-b, anticorps myl3.L, anticorps zgc:103441, anticorps myosin heavy chain 7, anticorps myosin, heavy polypeptide 7, cardiac muscle, beta, anticorps myosin, light polypeptide 3, anticorps myosin light chain 3, anticorps myosin light chain 3 S homeolog, anticorps cardiac myosin light chain-1, anticorps MYH7, anticorps Myh7, anticorps Myl3, anticorps MYL3, anticorps myl3.S, anticorps cmlc1

Sujet:

Description: Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.

Aliases: CMH8, VLC1, MLC1V, MLC1SB

Poids moléculaire: 22 kDa

ID gène: 4634

HGNC: 4634