NME1 anticorps

N° du produit ABIN969317

L’anticorps Souris Monoclonal anti-NME1 a été validé pour IHC, ELISA, ICC et FACS. Il convient pour détecter NME1 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour NME1 anticorps (ABIN969317)

Antigène: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NME1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 4B2

Détail du produit anti-NME1 anticorps

Fonction: NME1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human NME1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NME1 (ABIN969317)

Treharne, Giles Best, Mehta: "Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis." dans: FEBS letters, Vol. 583, Issue 17, pp. 2789-92, (2009) (PubMed).

Egistelli, Chichiarelli, Gaucci, Eufemi, Schininà, Giorgi, Lascu, Turano, Giartosio, Cervoni: "IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters." dans: Journal of cellular biochemistry, Vol. 106, Issue 4, pp. 666-72, (2009) (PubMed).

Lee, Jeong, Kim, Song, Kang, Lee: "Multiple functions of Nm23-H1 are regulated by oxido-reduction system." dans: PLoS ONE, Vol. 4, Issue 11, pp. e7949, (2009) (PubMed).

Détails sur NME1

Antigène: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Autre désignation: NME1

Sujet: Non-metastatic cells 1,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates,with a reduced expression in tumor progression to the metastatic phenotype,mutated in agressive neuroblastoma,expressed in lung carcinoma cell lines not in normal lung,pyrimidine biosynthetic pathway. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Has tumor metastasis-suppressive capacity.Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.

Poids moléculaire: 17 kDa

UniProt: P15531

Pathways: Apoptose, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process