PRKAA1 anticorps

N° du produit ABIN969364

Cet anticorps Souris Monoclonal détecte spécifiquement PRKAA1 dans WB, IHC, ELISA, ICC et FACS. Il présente une réactivité envers Humain, Souris, Rat et Singe et a été mentionné dans 2+ publications.

Aperçu rapide pour PRKAA1 anticorps (ABIN969364)

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRKAA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 2B7

Détail du produit anti-PRKAA1 anticorps

Fonction: PRKAA1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PRKAA1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PRKAA1 (ABIN969364)

Pan, Yang, Cao, Song, Wallin, Kivlin, Lu, Hu, Di, Wan: "AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells." dans: Oncology reports, Vol. 20, Issue 6, pp. 1553-9, (2008) (PubMed).

Egawa, Kamata, Kushiyama, Sakoda, Fujishiro, Horike, Yoneda, Nakatsu, Ying, Jun, Tsuchiya, Takata, Kurihara, Asano: "Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells." dans: Placenta, Vol. 29, Issue 12, pp. 1003-8, (2008) (PubMed).

Détails sur PRKAA1

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Autre désignation: PRKAA1

Sujet: The protein belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Poids moléculaire: 64 kDa

ID gène: 5562

UniProt: Q13131

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg