ROR1 anticorps (AA 30-406)

N° du produit ABIN969385

Cet anticorps Souris Monoclonal détecte spécifiquement ROR1 dans ELISA et ICC. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour ROR1 anticorps (AA 30-406) (ABIN969385)

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ROR1 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Clone: 2H6

Détail du produit anti-ROR1 anticorps

Épitope: AA 30-406

Fonction: ROR1 Antibody

Purification: Ascitic fluid

Immunogène: Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ROR1 (ABIN969385)

Paganoni, Ferreira: "Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2." dans: Journal of cell science, Vol. 118, Issue Pt 2, pp. 433-46, (2005) (PubMed).

Détails sur ROR1

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Autre désignation: ROR1

Sujet: ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

Poids moléculaire: 101 kDa

ID gène: 4919

UniProt: Q01973

Pathways: Signalisation RTK, Signalisation WNT, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha