SKP1 anticorps

N° du produit ABIN969397

Cet anticorps Souris Monoclonal détecte spécifiquement SKP1 dans WB, ELISA, IHC, ICC et FACS. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour SKP1 anticorps (ABIN969397)

Antigène: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SKP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 4E11

Détail du produit anti-SKP1 anticorps

Fonction: SKP1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human SKP1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-SKP1 (ABIN969397)

Werden, Lanchbury, Shattuck, Neff, Dufford, McFadden: "The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells." dans: Journal of virology, Vol. 83, Issue 23, pp. 12068-83, (2009) (PubMed).

Détails sur SKP1

Antigène: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Autre désignation: SKP1

Sujet: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Poids moléculaire: 19 kDa

UniProt: P63208

Pathways: Cycle Cellulaire, Signalisation Hedgehog, Mitotic G1-G1/S Phases