TRIM5 anticorps

N° du produit ABIN969443

L’anticorps Souris Monoclonal anti-TRIM5 a été validé pour WB, ELISA et IHC. Il convient pour détecter TRIM5 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour TRIM5 anticorps (ABIN969443)

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TRIM5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 3B11H2

Détail du produit anti-TRIM5 anticorps

Fonction: Trim5a Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human trim5 alpha expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-TRIM5 (ABIN969443)

Song, Javanbakht, Perron, Park, Stremlau, Sodroski: "Retrovirus restriction by TRIM5alpha variants from Old World and New World primates." dans: Journal of virology, Vol. 79, Issue 7, pp. 3930-7, (2005) (PubMed).

Keckesova, Ylinen, Towers: "The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10780-5, (2004) (PubMed).

Stremlau, Owens, Perron, Kiessling, Autissier, Sodroski: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." dans: Nature, Vol. 427, Issue 6977, pp. 848-53, (2004) (PubMed).

Détails sur TRIM5

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Autre désignation: Trim5a

Sujet: TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

ID gène: 85363

UniProt: Q9C035

Pathways: Activation of Innate immune Response