NCK1 anticorps

N° du produit ABIN969545

L’anticorps Souris Monoclonal anti-NCK1 a été validé pour WB, IHC, ELISA et FACS. Il convient pour détecter NCK1 dans des échantillons de Humain et Singe. Il y a 2+ publications disponibles.

Aperçu rapide pour NCK1 anticorps (ABIN969545)

Antigène: NCK1 (NCK Adaptor Protein 1 (NCK1))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NCK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 5B7

Détail du produit anti-NCK1 anticorps

Fonction: NCK1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human NCK1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NCK1 (ABIN969545)

Preisinger, Kolch: "The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway." dans: Cellular signalling, Vol. 22, Issue 5, pp. 848-56, (2010) (PubMed).

Blasutig, New, Thanabalasuriar, Dayarathna, Goudreault, Quaggin, Li, Gruenheid, Jones, Pawson: "Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization." dans: Molecular and cellular biology, Vol. 28, Issue 6, pp. 2035-46, (2008) (PubMed).

Détails sur NCK1

Antigène: NCK1 (NCK Adaptor Protein 1 (NCK1))

Autre désignation: NCK1

Sujet: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.

Poids moléculaire: 47 kDa

UniProt: P16333

Pathways: TCR Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals