RAP1A anticorps

N° du produit ABIN969561

Détail du produit anti-RAP1A anticorps

Antigène: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAP1A est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human RAP1A expressed in E. coli.

Clone: 5F8

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-RAP1A (ABIN969561)

Severson, Lee, Capaldo, Nusrat, Parkos: "Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration." dans: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1916-25, (2009) (PubMed).

Dao, Dupuy, Gavet, Caron, de Gunzburg: "Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis." dans: Journal of cell science, Vol. 122, Issue Pt 16, pp. 2996-3004, (2009) (PubMed).

Détails sur RAP1A

Antigène: RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

Autre désignation: RAP1A (RAP1A Produits)

Synonymes: anticorps KREV-1, anticorps KREV1, anticorps RAP1, anticorps SMGP21, anticorps AI848598, anticorps G-22K, anticorps Krev-1, anticorps Rap1, anticorps RAP-1A, anticorps rap 1A, anticorps wu:fc66g06, anticorps zgc:86676, anticorps krev-1, anticorps krev1, anticorps rap1, anticorps RAP1A, member of RAS oncogene family, anticorps RAS-related protein 1a, anticorps RAP1A, member of RAS oncogene family a, anticorps RAP1A, member of RAS oncogene family L homeolog, anticorps RAP1A, anticorps Rap1a, anticorps rap1aa, anticorps rap1a.L

Sujet:

Description: The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50 % amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

Aliases: RAP1, KREV1, KREV-1, SMGP21

Poids moléculaire: 21 kDa

ID gène: 5906

HGNC: 5906

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor