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Ataxin 2 Produits

(Ataxin 2 (ATXN2))
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined. [provided by RefSeq, Jan 2010].

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Catégories Ataxin 2 en vedette

Ataxin 2 Anticorps

High quality antibodies with extensive validation data.

Ataxin 2 Kits ELISA

Reliable ELISA kits for a wide range of species.

Ataxin 2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Ataxin 2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (5)
N° du produit ABIN7259314
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IF, ICC, FACS
Validations
  • (7)
N° du produit ABIN3028477
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
N° du produit ABIN872411
Quantité 100 μL
Fiche technique Fiche technique

Ataxin 2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962049
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1113614
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1113615
Quantité 96 tests
Fiche technique Fiche technique

Ataxin 2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (6)
N° du produit ABIN3089810
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7121916
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1346193
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Ataxin 2

Abraham, Chan, Salvi, Ho, Hall, Vidya, Guo, Killackey, Liu, Lee, Brown, Mekhail: "Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids." dans: Nucleic acids research, Vol. 44, Issue 18, pp. 8870-8884, (2016) (PubMed).

Xia, Santostefano, Hamazaki, Liu, Subramony, Terada, Ashizawa: "Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro." dans: Journal of molecular neuroscience : MN, Vol. 51, Issue 2, pp. 237-48, (2013) (PubMed).

Kaehler, Isensee, Nonhoff, Terrey, Hucho, Lehrach, Krobitsch: "Ataxin-2-like is a regulator of stress granules and processing bodies." dans: PLoS ONE, Vol. 7, Issue 11, pp. e50134, (2012) (PubMed).

Dubois, Trynka, Franke, Hunt, Romanos, Curtotti, Zhernakova, Heap, Adány, Aromaa, Bardella, van den Berg, Bockett, de la Concha, Dema, Fehrmann, Fernández-Arquero, Fiatal, Grandone, Green, Groen et al.: "Multiple common variants for celiac disease influencing immune gene expression. ..." dans: Nature genetics, Vol. 42, Issue 4, pp. 295-302, (2010) (PubMed).

Huynh, Del Bigio, Ho, Pulst: "Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2." dans: Annals of neurology, Vol. 45, Issue 2, pp. 232-41, (1999) (PubMed).

Nechiporuk, Huynh, Figueroa, Sahba, Nechiporuk, Pulst: "The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression." dans: Human molecular genetics, Vol. 7, Issue 8, pp. 1301-9, (1998) (PubMed).

Pulst, Nechiporuk, Nechiporuk, Gispert, Chen, Lopes-Cendes, Pearlman, Starkman, Orozco-Diaz, Lunkes, DeJong, Rouleau, Auburger, Korenberg, Figueroa, Sahba: "Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2." dans: Nature genetics, Vol. 14, Issue 3, pp. 269-76, (1996) (PubMed).

Synonymes et noms alternatifs relatifs à Ataxin 2

ataxin 2 (ATXN2), ataxin 2 (Atxn2), ataxin 2 L homeolog (atxn2.L), 9630045M23Rik, ASL13, ATX2, ATXN2, AW544490, MGC115230, SCA2, Sca2, TNRC13

Protein level used designations for Ataxin 2

  • ataxin-2
  • spinocerebellar ataxia type 2 protein
  • trinucleotide repeat containing 13
  • trinucleotide repeat-containing gene 13 protein
  • spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
  • spinocerebellar ataxia 2 homolog
  • spinocerebellar ataxia type 2 protein homolog
  • ataxin 2
  • ataxin-2-like
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