CASC5 Produits
(Cancer Susceptibility Candidate 5 (CASC5))
Catégories
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11\;15)(q23\;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013].
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Catégories CASC5 en vedette
CASC5 Anticorps
High quality antibodies with extensive validation data.
CASC5 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CASC5 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Rat
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN7256628
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
N° du produit
ABIN6137952
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
N° du produit
ABIN760391
Quantité
100 μL
Fiche technique
Fiche technique
CASC5 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1348085
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3135614
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7420573
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CASC5
: "Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment." dans: Scientific reports, Vol. 8, Issue 1, pp. 3888, (2019) (PubMed).: "TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment." dans: The Journal of cell biology, Vol. 209, Issue 2, pp. 221-34, (2015) (PubMed).
: "ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments." dans: Oncotarget, Vol. 6, Issue 39, pp. 41550-65, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à CASC5
kinetochore scaffold 1 (KNL1), kinetochore scaffold 1 (Knl1), Kinetochore null protein 1 (knl-1), 2310043D08Rik, 5730505K17Rik, AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Rad51, Spc7Protein level used designations for CASC5
- cancer susceptibility candidate 5
- ALL1-fused gene from chromosome 15q14 protein
- blinkin, bub-linking kinetochore protein
- cancer susceptibility candidate gene 5 protein
- cancer/testis antigen 29
- kinetochore null 1 homolog
- kinetochore-null protein 1
- protein CASC5
- protein phosphatase 1, regulatory subunit 55
- RAD51 homolog
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