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CBP Produits

(CREB Binding Protein (CREBBP))
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].

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Catégories CBP en vedette

CBP Anticorps

High quality antibodies with extensive validation data.

CBP Kits ELISA

Reliable ELISA kits for a wide range of species.

CBP Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

CBP recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF, IP, IHC (p), ICC, ChIP
Validations
  • (1)
  • (9)
  • (1)
N° du produit ABIN2854987
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (5)
N° du produit ABIN6260516
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (4)
N° du produit ABIN560465
Quantité 100 μg
Fiche technique Fiche technique

CBP recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955103
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955104
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1381381
Quantité 96 tests
Fiche technique Fiche technique

CBP recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122497
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1350309
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
N° du produit ABIN2669638
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits CBP

Zambanini, Nordin, Jonasson, Pagella, Cantù: "A new cut&run low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/b-catenin tissue-specific genomic targets." dans: Development (Cambridge, England), (2022) (PubMed).

Thamizhoviya, Vanisree: "Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress." dans: Metabolic brain disease, Vol. 34, Issue 3, pp. 875-887, (2020) (PubMed).

Li, Xu, Fu, Lei, Yao, Yang, Zhang, Washburn, Florens, Jaiswal, Wu, Mohan: "DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers." dans: Nucleic acids research, (2018) (PubMed).

Wu, Zhang, Cenciarini, Proietti, Amasino, Hong, Yang, Liao, Chiang, Kaklamani, Jeselsohn, Vadlamudi, Huang, Li, De Angelis, Fu, Elizalde, Schiff, Brown, Xu: "Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis." dans: Cancer research, Vol. 78, Issue 3, pp. 671-684, (2017) (PubMed).

Peifer, Fernández-Cuesta, Sos, George, Seidel, Kasper, Plenker, Leenders, Sun, Zander, Menon, Koker, Dahmen, Müller, Di Cerbo, Schildhaus, Altmüller, Baessmann, Becker, de Wilde, Vandesompele, Böhm et al.: "Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. ..." dans: Nature genetics, Vol. 44, Issue 10, pp. 1104-10, (2012) (PubMed).

Wood, Beaujeux, Shaw: "Protein aggregation in motor neurone disorders." dans: Neuropathology and applied neurobiology, Vol. 29, Issue 6, pp. 529-45, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à CBP

CREB binding protein (CREBBP), CREB binding protein (Crebbp), CREB binding protein L homeolog (crebbp.L), histone acetyltransferase p300 (LOC100123220), AW558298, CBP, cbp, CBP/p300, crebbp, hmm291030, KAT3A, kat3a, Nejire, p300/CBP, RSTS, rsts, RTS

Protein level used designations for CBP

  • CREB-binding protein
  • CREB binding protein (Rubinstein-Taybi syndrome)
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