The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011].
CLU
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos Clusterin Protéines
Son, Diamond, Volpe, Aranow, Mackay, Santiago-Schwarz: "Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression." dans: Scientific reports, Vol. 7, Issue 1, pp. 270, (2017) (PubMed).
Gil, Youn, Byun, Huang, Namkoong, Jang, Lee, Jo, Kang, Kim, Shin, Pietrzik, Lee, Kim, Kim: "Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway." dans: Nature communications, Vol. 4, pp. 1862, (2013) (PubMed).
Shim, Kang, Jeon, Park, Lee, Lee, Park, Lee, Schedin, Min: "Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages." dans: Journal of leukocyte biology, Vol. 90, Issue 4, pp. 761-9, (2011) (PubMed).
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." dans: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
Wong, Taillefer, Lakins, Pineault, Chader, Tenniswood: "Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration." dans: European journal of biochemistry / FEBS, Vol. 221, Issue 3, pp. 917-25, (1994) (PubMed).
Jenne, Tschopp: "Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 18, pp. 7123-7, (1989) (PubMed).