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Clusterin Protein (CLU) (AA 22-448, Nuclear) (His tag)
CLU
Origine: Souris
Hôte: Escherichia coli (E. coli)
Recombinant
>90 % (SDS-PAGE)
SDS
N° du produit ABIN1344140
Détail du produit
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Antigène
Voir toutes Clusterin (CLU) Protéines
Clusterin (CLU)
Type de proteíne
Recombinant
Attributs du protein
Nuclear, AA 22-448
Origine
Toutes les origines à travers Clusterin Protéines
Souris
Source
Toutes les sources à travers Clusterin Protéines
Escherichia coli (E. coli)
Purification/Conjugué
Cette Clusterin protéine est marqué à la His tag.
Application
SDS-PAGE (SDS)
Réactivité croisée
Souris
Attributs du produit
Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
Pureté
>90 % (SDS-PAGE)
Stérilité
0.2 μm filtered
niveau d'endotoxine
<1EU/μg purified protein (LAL test, Lonza).
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Discover our top product CLU Protéine
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
Lot specific
Buffer
0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
Stock
4 °C,-20 °C
Stockage commentaire
Short Term Storage: +4°C Long Term Storage: -20°C Working aliquots are stable for up to 3 months when stored at -20°C.
Date de péremption
3 months
Détail du antigène
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Antigène
Clusterin (CLU)
Autre désignation
Clusterin (CLU Produits )
Synonymes
LOC100136120 Protein, clu Protein, MGC53055 Protein, zgc:73352 Protein, xclu Protein, MGC89163 Protein, CLU Protein, APO-J Protein, APOJ Protein, CLI Protein, CLU1 Protein, CLU2 Protein, KUB1 Protein, NA1/NA2 Protein, SGP-2 Protein, SGP2 Protein, SP-40 Protein, TRPM-2 Protein, TRPM2 Protein, DAG Protein, RATTRPM2B Protein, SP40 Protein, TRPM2B Protein, Trpm2 Protein, Trpmb Protein, AI893575 Protein, ApoJ Protein, Cli Protein, D14Ucla3 Protein, Sgp-2 Protein, Sgp2 Protein, Sugp-2 Protein, GP80 Protein, gpIII Protein, 40 Protein, clusterin-1 Protein, clusterin L homeolog Protein, clusterin Protein, Clusterin Protein, LOC100136120 Protein, clu.L Protein, clu Protein, CLU Protein, clus Protein, Clu Protein, LOC101113728 Protein
Sujet
Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.
Poids moléculaire
~45kDa (SDS-PAGE)
UniProt
Q549A5
Pathways
Apoptose , Negative Regulation of intrinsic apoptotic Signaling
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