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DCLK2 Produits

(Doublecortin-Like Kinase 2 (DCLK2))

Catégories

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].

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Catégories DCLK2 en vedette

DCLK2 Anticorps

High quality antibodies with extensive validation data.

DCLK2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

DCLK2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IF, ICC
Validations
  • (3)
N° du produit ABIN6258107
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (3)
  • (1)
N° du produit ABIN1881253
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, ICC
Validations
  • (2)
N° du produit ABIN2856229
Quantité 100 μL
Fiche technique Fiche technique

DCLK2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN5648188
Quantité 96 tests
Fiche technique Fiche technique

DCLK2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5508892
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7421590
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7423801
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits DCLK2

Dijkmans, van Hooijdonk, Fitzsimons, Vreugdenhil: "The doublecortin gene family and disorders of neuronal structure." dans: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).

Kerjan, Koizumi, Han, Dubé, Djakovic, Patrick, Baram, Heinemann, Gleeson: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).

Gorelik, Sapir, Reiner: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." dans: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à DCLK2

doublecortin like kinase 2 (DCLK2), doublecortin-like kinase 2 (Dclk2), doublecortin-like kinase 2a (dclk2a), 6330415M09Rik, AU044875, cb572, CL2, CLICK-II, Click-II, CLICK2, CLIK2, DCAMKL2, Dcamkl2, DCDC3, DCDC3B, DCK2, Dck2, dclk, DCLK2, RGD1308384, sb:cb572, si:dkey-180n16.1

Protein level used designations for DCLK2

  • CaMK-like CREB regulatory kinase 2
  • doublecortin and CaM kinase-like 2
  • doublecortin domain-containing protein 3B
  • doublecortin-like and CAM kinase-like 2
  • serine/threonine-protein kinase DCLK2
  • caMK-like CREB regulatory kinase 2
  • doublecortin-like kinase 2
  • zDCLK
  • doublecortin kinase 2
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