ErbB2/Her2 Produits
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
Catégories
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
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Catégories ErbB2/Her2 en vedette
ErbB2/Her2 Anticorps
High quality antibodies with extensive validation data.
ErbB2/Her2 Kits ELISA
Reliable ELISA kits for a wide range of species.
ErbB2/Her2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ErbB2/Her2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
N° du produit
ABIN7444448
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Avian, Cat, Chicken, Cow, Dog, Donkey, Goat, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
Application
WB
Validations
- (7)
N° du produit
ABIN6254225
Quantité
600 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), PLA
Validations
- (7)
N° du produit
ABIN515370
Quantité
100 μg
Fiche technique
Fiche technique
ErbB2/Her2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
N° du produit
ABIN6730948
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6959063
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6973408
Quantité
96 tests
Fiche technique
Fiche technique
ErbB2/Her2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
N° du produit
ABIN7274799
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
N° du produit
ABIN7274796
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
N° du produit
ABIN7274800
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ErbB2/Her2
: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." dans: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity." dans: Nature communications, Vol. 9, Issue 1, pp. 3049, (2019) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
Synonymes et noms alternatifs relatifs à ErbB2/Her2
erb-b2 receptor tyrosine kinase 2 (ERBB2), erb-b2 receptor tyrosine kinase 2 (Erbb2), erb-b2 receptor tyrosine kinase 2 (erbb2), c-erbB2, c-neu, CD340, erb2, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, NEU, Neu, NGL, TKR1, wu:fv70f10, zgc:63601Protein level used designations for ErbB2/Her2
- c-erb B2/neu protein
- herstatin
- metastatic lymph node gene 19 protein
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- p185erbB2
- proto-oncogene Neu
- proto-oncogene c-ErbB-2
- receptor tyrosine-protein kinase erbB-2
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- Neu oncogene
- avian erythroblastosis oncogene B 2
- c-erbB-2
- proto-oncogene NEU
- erbB-2
- Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
- C-erbB-2
- NEU proto-oncogene
- epidermal growth factor receptor-related protein
- p185neu
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- epidermal growth factor receptor type 2
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