ErbB2/Her2 Protéines
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| ErbB2/Her2 Protein (AA 23-652) (His-Avi Tag) | Humain | HEK-293 Cells |
|
380,58 €
Voir le prix
|
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| ErbB2/Her2 Protein (AA 23-652) (Biotin,His-Avi Tag) | Humain | HEK-293 Cells |
|
628,47 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (Fc Tag) | Humain | HEK-293 Cells |
|
872,31 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (His tag) | Cynomolgus | HEK-293 Cells |
|
347,53 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 489-630) (His-Avi Tag) | Humain | HEK-293 Cells |
|
350,54 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (His tag) | Humain | HEK-293 Cells |
|
872,31 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 489-630) (Biotin,His-Avi Tag) | Humain | HEK-293 Cells |
|
628,47 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 1-1255) (GST tag) | Humain | Wheat germ |
|
624,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 511-630) (His tag) | Humain | Escherichia coli (E. coli) |
|
419,69 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 67-323) (His-IF2DI Tag) | Rat | Escherichia coli (E. coli) |
|
476,92 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (His tag) | Humain | Baculovirus infected Insect Cells |
|
1.150,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Fc Tag) | Rat | HEK-293 Cells |
|
866,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 4-656) (His tag) | Rat | HEK-293 Cells |
|
866,00 €
Voir le prix
|
|
| ErbB2/Her2 Protéine | Rat | HEK-293 Cells |
|
962,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Fc Tag) | Souris | HEK-293 Cells |
|
866,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (His tag) | Souris | HEK-293 Cells |
|
866,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 22-121) (GST tag) | Humain | Wheat germ |
|
624,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (Fc-Avi Tag,Biotin) | Humain | HEK-293 Cells |
|
1.034,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-510) (His tag) | Humain | HEK-293 Cells |
|
543,95 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) | Humain | HEK-293 Cells |
|
502,55 €
Voir le prix
|
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- ScA (Screening Assay: Application indiquée)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Cynomolgus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- ScA (Screening Assay: Application indiquée)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- AP (Affinity Purification: Application indiquée)
- AA (Antibody Array: Application indiquée)
- ELISA (ELISA: Application indiquée)
- WB (Western Blotting: Application indiquée)
2 références - Origine
- Humain
- Hôte
- Wheat germ
- Type Proteine
- Recombinant
Protein
- WB (Western Blotting: Image de validation disponible)
- ELISA (ELISA: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: Image de validation disponible)
- ELISA (ELISA: Application indiquée)
- Origine
- Rat
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Pureté
- > 85 %
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Rat
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 85 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Rat
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Rat
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 92 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: Image de validation disponible)
- ELISA (ELISA: Application indiquée)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 90 % as determined by reducing SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- AP (Affinity Purification: Application indiquée)
- AA (Antibody Array: Application indiquée)
- ELISA (ELISA: Application indiquée)
- WB (Western Blotting: Application indiquée)
- Origine
- Humain
- Hôte
- Wheat germ
- Type Proteine
- Recombinant
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 90 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Dernières publications pour nos ErbB2/Her2 Protéines
: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." dans: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." dans: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." dans: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
Pseudonymes pour ErbB2/Her2 Protéines
erb-b2 receptor tyrosine kinase 2 (ERBB2) Protéineserb-b2 receptor tyrosine kinase 2 (Erbb2) Protéines
erb-b2 receptor tyrosine kinase 2 (erbb2) Protéines
c-erbB2 Protéines
c-neu Protéines
CD340 Protéines
erb2 Protéines
Erbb-2 Protéines
HER-2 Protéines
HER-2/neu Protéines
HER2 Protéines
mKIAA3023 Protéines
MLN 19 Protéines
NEU Protéines
Neu Protéines
NGL Protéines
TKR1 Protéines
wu:fv70f10 Protéines
zgc:63601 Protéines
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