(Fas (TNFRSF6)-Associated Via Death Domain (FADD))
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].
custom-made
FADD
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
FADD
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
FADD
Origine: Souris
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
custom-made
FADD
Origine: Humain
Hôte: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
García-Fuster, Ramos-Miguel, Miralles, García-Sevilla et al.: "Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ..." dans: Neuropharmacology, Vol. 55, Issue 5, pp. 886-99, (2008) (PubMed).
Pseudonymes pour FADD Protéines
Fas associated via death domain (FADD) Protéines Fas (TNFRSF6)-associated via death domain (Fadd) Protéines Fas associated via death domain (Fadd) Protéines Fas associated via death domain S homeolog (fadd.S) Protéines Fas (tnfrsf6)-associated via death domain (fadd) Protéines adaptor Protéines fadd Protéines MORT1 Protéines Mort1 Protéines mort1 Protéines Mort1/FADD Protéines TNFRSF6 Protéines xfadd Protéines