(Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." dans: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." dans: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." dans: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." dans: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).
Pseudonymes pour FCGR2B Protéines
Fc fragment of IgG receptor IIb (FCGR2B) Protéines Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B) Protéines Fc receptor, IgG, low affinity IIb (Fcgr2b) Protéines Fc fragment of IgG receptor IIb (Fcgr2b) Protéines low affinity immunoglobulin gamma Fc region receptor II (LOC100856270) Protéines AI528646 Protéines CD32 Protéines CD32B Protéines F630109E10Rik Protéines FCG2 Protéines FCGR2 Protéines Fcgr2 Protéines Fcgr2a Protéines FCGR2B Protéines FcgRII Protéines Fcr-2 Protéines Fcr-3 Protéines FCRII Protéines FcRII Protéines Fc[g]RII Protéines IGFR2 Protéines Ly-17 Protéines Ly-m20 Protéines LyM-1 Protéines Lym-1 Protéines