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FEN1 Produits

(Flap Structure-Specific Endonuclease 1 (FEN1))

Catégories

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].

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Catégories FEN1 en vedette

FEN1 Anticorps

High quality antibodies with extensive validation data.

FEN1 Kits ELISA

Reliable ELISA kits for a wide range of species.

FEN1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

FEN1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF, IP
Validations
  • (6)
N° du produit ABIN3021632
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF, IP, IHC (p), ICC, PLA
Validations
  • (6)
N° du produit ABIN2855166
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, IHC, IF
Validations
  • (5)
N° du produit ABIN7255764
Quantité 200 μL
Fiche technique Fiche technique

FEN1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955927
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1133432
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6217033
Quantité 96 tests
Fiche technique Fiche technique

FEN1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353955
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353954
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3092557
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits FEN1

Moreli, Santos, Lorenzon-Ojea, Corrêa-Silva, Fortunato, Rocha, Rudge, Damasceno, Bevilacqua, Calderon: "Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response." dans: International journal of biological sciences, Vol. 12, Issue 4, pp. 466-77, (2016) (PubMed).

Duxin, Moore, Sidorova, Karanja, Honaker, Dao, Piwnica-Worms, Campbell, Monnat, Stewart: "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication." dans: The Journal of biological chemistry, Vol. 287, Issue 26, pp. 21980-91, (2012) (PubMed).

Jaiswal, Armas, Izumi, Strauss, Narayan: "Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function." dans: Neoplasia (New York, N.Y.), Vol. 14, Issue 6, pp. 495-508, (2012) (PubMed).

Ma, Liang, Liu, Axcrona, Kvalheim, Stokke, Nesland, Suo: "Prostate cancer cell lines under hypoxia exhibit greater stem-like properties." dans: PLoS ONE, Vol. 6, Issue 12, pp. e29170, (2012) (PubMed).

Tann, Boldogh, Meiss, Qian, Van Houten, Mitra, Szczesny: "Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair." dans: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 31975-83, (2011) (PubMed).

Jaiswal, Narayan: "Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity." dans: Biochemistry, Vol. 50, Issue 11, pp. 1901-9, (2011) (PubMed).

Asagoshi, Liu, Masaoka, Lan, Prasad, Horton, Brown, Wang, Bdour, Sobol, Taylor, Yasui, Wilson: "DNA polymerase beta-dependent long patch base excision repair in living cells." dans: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).

Saharia, Teasley, Duxin, Dao, Chiappinelli, Stewart: "FEN1 ensures telomere stability by facilitating replication fork re-initiation." dans: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27057-66, (2010) (PubMed).

Guo, Zheng, Xu, Dai, Zhou, Pascua, Chen, Shen: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." dans: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).

Sampathi, Bhusari, Shen, Chai: "Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance." dans: The Journal of biological chemistry, Vol. 284, Issue 6, pp. 3682-90, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à FEN1

flap structure-specific endonuclease 1 (FEN1), flap endonuclease 1-like (LOC100808044), Flap endonuclease-1 (Bm1_49605), 5'-3' exonuclease family protein (AT5G26680), flap structure specific endonuclease 1 (Fen1), flap structure-specific endonuclease 1 (fen1), flap structure-specific endonuclease 1 L homeolog (fen1.L), flap structure-specific endonuclease 1 (Fen1), nuclease, Rad2 family (FEN1), AW538437, cb879, FEN-1, fen-1, FEN1, fen1, MF1, mf1, RAD2, rad2, xFEN1a

Protein level used designations for FEN1

  • flap endonuclease 1
  • Flap structure-specific endonuclease 1
  • flap structure-specific endonuclease 1
  • DNase IV
  • maturation factor 1
  • maturation factor-1
  • 5' nuclease xFEN1a
  • FEN-1-A
  • flap endonuclease 1-A
  • flap structure-specific endonuclease 1-A
  • xFEN-1a
  • FEN-1
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