Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

FDPS Produits

(Farnesyl Diphosphate Synthase (FDPS))

Catégories

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories FDPS en vedette

FDPS Anticorps

High quality antibodies with extensive validation data.

FDPS Kits ELISA

Reliable ELISA kits for a wide range of species.

FDPS Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

FDPS recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC (p), ICC, IF
Validations
  • (5)
N° du produit ABIN2856081
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IP
Validations
  • (4)
N° du produit ABIN7152571
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p), IF
Validations
  • (2)
  • (3)
N° du produit ABIN1882080
Quantité 400 μL
Fiche technique Fiche technique

FDPS recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6955697
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955696
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6951338
Quantité 96 tests
Fiche technique Fiche technique

FDPS recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353934
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353936
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7504326
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits FDPS

Chimenti, Camprubí-Rimblas, Guillamat-Prats, Gomez, Tijero, Blanch, Artigas: "Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injury." dans: Thrombosis and haemostasis, Vol. 117, Issue 11, pp. 2125-2134, (2018) (PubMed).

Sousa, Auriola, Mönkkönen, Määttä: "Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells." dans: BMC cancer, Vol. 15, pp. 4, (2015) (PubMed).

Todenhöfer, Hennenlotter, Kühs, Gerber, Gakis, Vogel, Aufderklamm, Merseburger, Knapp, Stenzl, Schwentner: "Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?" dans: World journal of urology, Vol. 31, Issue 2, pp. 345-50, (2013) (PubMed).

Miyazaki, Kato, Tanaka, Tanaka, Takao, Kohjima, Ito, Enjoji, Nakamuta, Kotoh, Takayanagi: "Antithrombin III injection via the portal vein suppresses liver damage." dans: World journal of gastroenterology, Vol. 18, Issue 16, pp. 1884-91, (2012) (PubMed).

Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." dans: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

Ishimoto, Tachibana, Hanano, Yamasaki, Nakamura, Kawai, Urano, Tanaka, Hamakubo, Sakai, Kodama, Doi: "Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells." dans: The Biochemical journal, Vol. 429, Issue 2, pp. 347-57, (2010) (PubMed).

Räikkönen, Mönkkönen, Auriola, Mönkkönen: "Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells." dans: Biochemical pharmacology, Vol. 79, Issue 5, pp. 777-83, (2010) (PubMed).

Li, Herold, Kimmel, Müller, Rincon-Orozco, Kunzmann, Herrmann: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 8118-24, (2009) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Wilkin, Kutsunai, Edwards et al.: "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ..." dans: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4607-14, (1990) (PubMed).

Synonymes et noms alternatifs relatifs à FDPS

Farnesyl pyrophosphate synthase (Fpps), farnesyl diphosphate synthase (fdps), farnesyl diphosphate synthase L homeolog (fdps.L), farnesyl pyrophosphate synthase (MGG_08649), farnesyl pyrophosphate synthetase (TP03_0857), farnesyl pyrophosphate synthetase (Tb09.160.4300), farnesyl-pyrophosphate synthetase (fpp), farnesyl pyrophosphate synthetase (BBOV_I000120), FDP synthase (fps), Farnesyl pyrophosphate synthetase (fpps), farnesyl diphosphate synthase (FDPS), farnesyl diphosphate synthase (Fdps), farnesyl diphosphate synthetase (Fdps), farnesyl pyrophosphate synthase 1 (fps1), (2E, 16.m00760, 6030492I17Rik, Ac2-125, AI256750, CG12389, DDBDRAFT_0206220, DDBDRAFT_0215017, DDB_0206220, DDB_0215017, Dmel\\CG12389, DmFPPS, DmFPPSase, DmFPS, Fdpsl1, fpps, FPPS, FPS, fps, l(2)k06103, mKIAA1293, NCU01175.1, v(2)k03514

Protein level used designations for FDPS

  • farnesyl pyrophosphate synthase
  • CG12389-PA
  • Fpps-PA
  • farnesyl diphosphate synthase
  • farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
  • farnesyl pyrophosphate synthetase
  • Farnesyl pyrophosphate synthetase
  • (2E,6E)-farnesyl diphosphate synthase
  • FPP synthase
  • FPP synthetase
  • dimethylallyltranstransferase
  • farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
  • geranyltranstransferase
  • CR 39
  • cholesterol-regulated 39 kDa protein
  • farnesyl diphosphate synthetase
  • testis-specific farnesyl pyrophosphate synthetase
  • FPS
  • 6E)-farnesyl diphosphate synthase
  • FPPS
  • GRMZM2G168681
  • PCO074380
  • PCO074380(592)
  • PCO074380_ov
  • PCO074380b
  • QBB18h08
  • geranylgeranyl-diphosphate synthase
  • gnp_QBB18h08b
  • gpm430b
  • prenyltransferase
Vous êtes ici:
Support technique