FE65 Produits
(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
Catégories
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
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Catégories FE65 en vedette
FE65 Anticorps
High quality antibodies with extensive validation data.
FE65 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FE65 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
N° du produit
ABIN3043784
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7144040
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
- (2)
N° du produit
ABIN725075
Quantité
100 μL
Fiche technique
Fiche technique
FE65 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345278
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345280
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345282
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits FE65
: "Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation." dans: Scientific reports, Vol. 5, pp. 11529, (2015) (PubMed).: "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development." dans: The EMBO journal, Vol. 25, Issue 2, pp. 420-31, (2006) (PubMed).
: "FE65 interaction with the ApoE receptor ApoEr2." dans: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24521-30, (2006) (PubMed).
: "Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)." dans: Molecular biology of the cell, Vol. 18, Issue 1, pp. 201-10, (2006) (PubMed).
: "The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65." dans: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41182-8, (2003) (PubMed).
: "The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway." dans: Biochemistry, Vol. 42, Issue 12, pp. 3627-34, (2003) (PubMed).
: "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins." dans: Biochemistry, Vol. 42, Issue 22, pp. 6664-73, (2003) (PubMed).
: "A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60." dans: Science (New York, N.Y.), Vol. 293, Issue 5527, pp. 115-20, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à FE65
amyloid beta precursor protein binding family B member 1 (APBB1), amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog (apbb1.L), amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1), amyloid beta precursor protein binding family B member 1 (Apbb1), apbb1, FE65, Fe65, MGC80654, MGC:9072, RIR, RirProtein level used designations for FE65
- adaptor protein FE65a2
- amyloid beta A4 precursor protein-binding family B member 1
- stat-like protein
- amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
- amyloid beta A4 precursor protein-binding, family B, member 1
- amyloid beta precursor protein-binding B1
- amyloid beta A4 precursor protein-binding family B member 1-like
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