FKBP4 Produits
(FK506 Binding Protein 4, 59kDa (FKBP4))
Catégories
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008].
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Catégories FKBP4 en vedette
FKBP4 Anticorps
High quality antibodies with extensive validation data.
FKBP4 Kits ELISA
Reliable ELISA kits for a wide range of species.
FKBP4 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FKBP4 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IP, ELISA, IHC (p)
Validations
- (2)
- (8)
N° du produit
ABIN560907
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (7)
N° du produit
ABIN7441208
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP
Validations
- (8)
N° du produit
ABIN949997
Quantité
100 μL
Fiche technique
Fiche technique
FKBP4 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955922
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4882894
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1147317
Quantité
96 tests
Fiche technique
Fiche technique
FKBP4 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1354126
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN5570541
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354128
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits FKBP4
: "The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets." dans: Molecular & cellular proteomics : MCP, Vol. 13, Issue 12, pp. 3585-601, (2014) (PubMed).: "Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs." dans: International journal of molecular sciences, Vol. 13, Issue 12, pp. 15536-64, (2013) (PubMed).
: "Investigation of SSEA-4 binding protein in breast cancer cells." dans: Journal of the American Chemical Society, Vol. 135, Issue 16, pp. 5934-7, (2013) (PubMed).
: "High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays." dans: Journal of proteome research, Vol. 12, Issue 5, pp. 2311-20, (2013) (PubMed).
: "Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins." dans: ACS chemical biology, Vol. 6, Issue 12, pp. 1357-66, (2011) (PubMed).
: "Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 14, pp. 4733-41, (2009) (PubMed).
: "Pharmacologic unmasking of epigenetically silenced genes in breast cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 4, pp. 1184-91, (2009) (PubMed).
: "Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 33-8, (2008) (PubMed).
: "The switch I region of Rheb is critical for its interaction with FKBP38." dans: The Journal of biological chemistry, Vol. 283, Issue 38, pp. 25963-70, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à FKBP4
FK506 binding protein 4 (FKBP4), FK506 binding protein 4 S homeolog (fkbp4.S), FK506 binding protein 4 (fkbp4), FK506 binding protein 4 (Fkbp4), 59kDa, AL022792, AW208983, FKBP-4, FKBP-52, FKBP51, fkbp52, FKBP52, fkbp59, FKBP59, FKPB52, HBI, hsp56, Hsp56, MGC81078, p52, p59, P59, PPIase, wu:fb34f09Protein level used designations for FKBP4
- peptidyl-prolyl cis-trans isomerase FKBP4
- FK506-binding protein 4
- FK506 binding protein 4, 59kDa
- peptidyl-prolyl cis-trans isomerase FKBP4-like
- 52 kDa FK506-binding protein
- 52 kDa FKBP
- 59 kDa immunophilin
- FKBP59
- HBI
- HSP-binding immunophilin
- PPIase FKBP4
- immunophilin FKBP52
- rotamase
- FK506 binding protein 52
- FKBP52 protein
- 51 kDa FK506-binding protein
- FK506-binding protein 4 (59kD)
- HSP binding immunophilin
- T-cell FK506-binding protein, 59kD
- peptidylprolyl cis-trans isomerase
- hsp90 binding protein
- p59 protein
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