GCH1 Produits
(GTP Cyclohydrolase 1 (GCH1))
Catégories
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].
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Catégories GCH1 en vedette
GCH1 Anticorps
High quality antibodies with extensive validation data.
GCH1 Kits ELISA
Reliable ELISA kits for a wide range of species.
GCH1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GCH1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), IP
Validations
- (11)
- (6)
N° du produit
ABIN561018
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (4)
N° du produit
ABIN7267525
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (3)
N° du produit
ABIN302137
Quantité
100 μg
Fiche technique
Fiche technique
GCH1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1135670
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1135671
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1135672
Quantité
96 tests
Fiche technique
Fiche technique
GCH1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1354910
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354912
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN3121448
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits GCH1
: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." dans: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." dans: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).
: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." dans: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).
: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." dans: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).
: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." dans: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).
: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).
: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." dans: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).
: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." dans: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).
: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." dans: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).
: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." dans: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à GCH1
GTP cyclohydrolase 1 (GCH1), GTP cyclohydrolase 1 (Gch1), GTP cyclohydrolase 1 (gch1), GTP cyclohydrolase 1 (Weevi_1190), GTP cyclohydrolase 1 (Halhy_0838), GTP cyclohydrolase 1 (Sinme_1220), GTP cyclohydrolase 1 (Sphch_1077), GTP cyclohydrolase 1-like (LOC100136794), DYT5, DYT5a, DYT14, GCH, Gch, gch1a, GTP-CH, GTP-CH-1, GTPCH, GTPCH1, HPABH4B, MGC89622, wu:fc16b10, zgc:195269Protein level used designations for GCH1
- GTP cyclohydrolase I
- GTP-CH-I
- dystonia 14
- guanosine 5'-triphosphate cyclohydrolase I
- GTP cyclohydrolase 1 (dopa-responsive dystonia)
- GTP cyclohydrolase 1
- GTP cyclohydrolase I (form A; N-terminus)
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