GCLC Produits
(Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
Catégories
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010].
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Catégories GCLC en vedette
GCLC Anticorps
High quality antibodies with extensive validation data.
GCLC Kits ELISA
Reliable ELISA kits for a wide range of species.
GCLC Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GCLC recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (6)
- (7)
N° du produit
ABIN561050
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN655884
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (1)
- (5)
N° du produit
ABIN2774078
Quantité
100 μL
Fiche technique
Fiche technique
GCLC recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6956167
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967068
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6956168
Quantité
96 tests
Fiche technique
Fiche technique
GCLC recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123113
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354922
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354924
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits GCLC
: "Overexpression of Brg1 Alleviates Hepatic Ischemia/Reperfusion-Induced Acute Lung Injury through Antioxidative Stress Effects." dans: Oxidative medicine and cellular longevity, Vol. 2017, pp. 8787392, (2018) (PubMed).: "Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks." dans: Biological trace element research, Vol. 186, Issue 1, pp. 226-237, (2018) (PubMed).
: "Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice." dans: PLoS ONE, Vol. 13, Issue 5, pp. e0198139, (2018) (PubMed).
: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." dans: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).
: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).
: "Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7752-61, (2016) (PubMed).
: "Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modulation of the ERK1/2 signaling pathway." dans: Neural regeneration research, Vol. 11, Issue 7, pp. 1090-8, (2016) (PubMed).
: "Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake." dans: The Journal of biological chemistry, Vol. 290, Issue 36, pp. 21788-99, (2015) (PubMed).
: "Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus." dans: PLoS ONE, Vol. 9, Issue 4, pp. e94460, (2014) (PubMed).
: "Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress." dans: Neoplasia (New York, N.Y.), Vol. 16, Issue 9, pp. 710-22, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à GCLC
glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase, catalytic subunit (gclc), Glutamate-cysteine ligase catalytic subunit (Gclc), gamma glutamylcysteine synthetase (LbGCS), gamma glutamylcysteine synthetase (gcsA), glutamate-cysteine ligase, catalytic subunit L homeolog (gclc.L), glutamate-cysteine ligase, catalytic subunit S homeolog (gclc.S), gamma-glutamylcysteine synthetase (GSH1), glutamate-cysteine ligase, catalytic subunit (Gclc), glutamate-cysteine ligase catalytic subunit (Gclc), 2259, cb1049, CG2259, D9Wsu168e, DDBDRAFT_0186120, DDBDRAFT_0231403, DDB_0186120, DDB_0231403, Dmel\\CG2259, DmGCLC, DmGCS, DmGCSh, fe36e11, GCL, GCLC, gclc, GCLc, Gcs, GCS, GCSh, Gcsh, Ggcs-hs, GLCL, GLCL-H, GLCLC, Glclc, MGC146287, wu:fe36e11Protein level used designations for GCLC
- glutamate--cysteine ligase catalytic subunit
- glutamate-cysteine ligase, catalytic subunit
- CG2259-PA
- CG2259-PB
- Gclc-PA
- Gclc-PB
- gamma-Glutamylcysteine synthetase
- gamma-Glutamylcysteine synthetase catalytic subunit
- gamma-glutamylcysteine ligase
- glutamate cysteine ligase
- glutamate-cysteine ligase
- gamma glutamylcysteine synthetase
- gamma-ECS
- glutamate--cysteine ligase, chloroplastic
- GCS heavy chain
- gamma-glutamylcysteine synthetase
- gamma GCS-HS
- gamma-glutamylcysteine synthetase heavy subunit
- Glutamylcysteine gamma synthetase light chain
- glutamate-cysteine ligase catalytic subunit
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