GCK Produits
(Glucokinase (Hexokinase 4) (GCK))
Catégories
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009].
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Catégories GCK en vedette
GCK Anticorps
High quality antibodies with extensive validation data.
GCK Kits ELISA
Reliable ELISA kits for a wide range of species.
GCK Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GCK recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (6)
N° du produit
ABIN515989
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (3)
N° du produit
ABIN969172
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
N° du produit
ABIN7429088
Quantité
100 μL
Fiche technique
Fiche technique
GCK recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6956118
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967028
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6963157
Quantité
96 tests
Fiche technique
Fiche technique
GCK recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354918
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354920
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123102
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits GCK
: "Hypoglycemic effects of wheat bran alkyresorcinols in high-fat/high-sucrose diet and low-dose streptozotocin-induced type 2 diabetic male mice and protection of pancreatic β cells." dans: Food & function, Vol. 10, Issue 6, pp. 3282-3290, (2019) (PubMed).: "Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt." dans: Frontiers in pharmacology, Vol. 10, pp. 261, (2019) (PubMed).
: "Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway." dans: Journal of agricultural and food chemistry, Vol. 66, Issue 26, pp. 6772-6781, (2018) (PubMed).
: "Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats." dans: Life sciences, Vol. 194, pp. 196-204, (2018) (PubMed).
: "Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus." dans: Journal of diabetes research, Vol. 2017, pp. 5812607, (2017) (PubMed).
: "Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." dans: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).
: "MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ." dans: RNA (New York, N.Y.), Vol. 21, Issue 3, pp. 385-400, (2015) (PubMed).
: "The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats." dans: PLoS ONE, Vol. 10, Issue 7, pp. e0131198, (2015) (PubMed).
: "Role of glucokinase in the subcellular localization of glucokinase regulatory protein." dans: International journal of molecular sciences, Vol. 16, Issue 4, pp. 7377-93, (2015) (PubMed).
: "Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene." dans: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1983-9, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à GCK
glucokinase (GCK), glucokinase (Gck), glucokinase (glcK), glucokinase (Bphyt_1025), glucokinase (Halhy_6548), glucokinase (gk), glucokinase (hexokinase 4) L homeolog (gck.L), glucokinase (hexokinase 4) (gck), BA4487, FGQTL3, GCK, gck-A, GK, Gk, GLK, glk, Gls006, glucokinase, GLUKA, HHF3, hhf3, HK4, hk4, HKIV, hkiv, HXKP, hxkp, LGLK, MODY2, mody2, RNGK2Protein level used designations for GCK
- ATP:D-hexose 6-phosphotransferase
- HK IV
- glucokinase
- hexokinase D, pancreatic isozyme
- hexokinase type IV
- hexokinase-4
- hexokinase-D
- hexokinase 4
- glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
- HK4
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