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GREM1 Produits

(Gremlin 1 (GREM1))
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

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Catégories GREM1 en vedette

GREM1 Anticorps

High quality antibodies with extensive validation data.

GREM1 Kits ELISA

Reliable ELISA kits for a wide range of species.

GREM1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GREM1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB
Validations
  • (9)
  • (7)
N° du produit ABIN390078
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (5)
N° du produit ABIN687082
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
N° du produit ABIN7434692
Quantité 100 μL
Fiche technique Fiche technique

GREM1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (9)
  • (6)
N° du produit ABIN6730963
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6962271
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6967209
Quantité 96 tests
Fiche technique Fiche technique

GREM1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
  • (5)
N° du produit ABIN6119725
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (2)
N° du produit ABIN4949105
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123201
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits GREM1

Qin, Jiang, Meng: "Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells." dans: Journal of diabetes research, Vol. 2020, pp. 9238742, (2021) (PubMed).

Droguett, Valderrama, Burgos, Carpio, Saka, Egido, Ruiz-Ortega, Mezzano: "Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis." dans: Scientific reports, Vol. 9, Issue 1, pp. 6867, (2020) (PubMed).

Kim, Sung, Youn, Park: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." dans: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).

Chatterjee, Behrendt, Schmid, Beck, Schneider, Mack, Müller, Geisler, Gawaz: "Platelets as a novel source of Gremlin-1: Implications for thromboinflammation." dans: Thrombosis and haemostasis, Vol. 117, Issue 2, pp. 311-324, (2018) (PubMed).

Tekari, May, Frauchiger, Chan, Benneker, Gantenbein: "The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells." dans: European cells & materials, Vol. 33, pp. 197-210, (2017) (PubMed).

Ruiz-Carpio, Sandoval, Aguilera, Albar-Vizcaíno, Perez-Lozano, González-Mateo, Acuña-Ruiz, García-Cantalejo, Botías, Bajo, Selgas, Sánchez-Tomero, Passlick-Deetjen, Piecha, Büchel, Steppan et al.: "Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. ..." dans: Scientific reports, Vol. 7, pp. 44941, (2017) (PubMed).

Hu, Sun, Gui, Sui: "Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells." dans: Molecular medicine reports, Vol. 15, Issue 4, pp. 2186-2194, (2017) (PubMed).

Yin, Yang, Yang, Yang, Li, Liu, Qu: "Overexpression of Gremlin promotes non-small cell lung cancer progression." dans: Tumour biology, Vol. 37, Issue 2, pp. 2597-602, (2016) (PubMed).

Han, Yoo, Kim, Hwang, Cho, You, Kim: "GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness." dans: The Journal of rheumatology, Vol. 43, Issue 3, pp. 474-85, (2016) (PubMed).

Barnes, Kucera, Tian, Mellor, Dvorina, Baldwin, Aldred, Farver, Comhair, Aytekin, Dweik: "Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension." dans: American journal of respiratory cell and molecular biology, Vol. 55, Issue 4, pp. 564-575, (2016) (PubMed).

Synonymes et noms alternatifs relatifs à GREM1

gremlin 1a, DAN family BMP antagonist (grem1a), gremlin 1, DAN family BMP antagonist (GREM1), gremlin 1 (LOC662541), gremlin 1, DAN family BMP antagonist (grem1), gremlin 1, DAN family BMP antagonist (Grem1), gremlin 1, DAN family BMP antagonist L homeolog (grem1.L), Cktsf1b1, CKTSF1B1, cktsf1b1, dand2, DAND2, drm, Drm, DRM, Grem, grem1, GREM1, gremlin, GREMLIN, gremlin-1, ihg-2, IHG-2, ld, MGC136702, pig2, zgc:136702

Protein level used designations for GREM1

  • gremlin 1 homolog a, cysteine knot superfamily
  • gremlin 1 homolog, cysteine knot superfamily
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
  • gremlin 1
  • GLEAN_07044
  • cysteine knot superfamily 1
  • cysteine knot superfamily 1, BMP antagonist 1
  • down-regulated in Mos-transformed cells protein
  • down-regulated in v-mos-transformed cells
  • gremlin-1
  • gremlin 1, cysteine knot superfamily, homolog
  • Cysteine knot superfamily 1, BMP antagonist 1
  • DAN domain family member 2
  • cell proliferation-inducing gene 2 protein
  • gremlin 1-like protein
  • increased in high glucose-2
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