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HAP1 Produits

(Huntingtin Associated Protein 1 (HAP1))
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

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Catégories HAP1 en vedette

HAP1 Anticorps

High quality antibodies with extensive validation data.

HAP1 Kits ELISA

Reliable ELISA kits for a wide range of species.

HAP1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

HAP1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse, Rat
Application WB, IF
Validations
  • (5)
  • (4)
N° du produit ABIN968461
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, IHC (p), IHC (fro)
Validations
  • (2)
  • (2)
N° du produit ABIN534035
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
N° du produit ABIN334416
Quantité 100 μg
Fiche technique Fiche technique

HAP1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956609
Quantité 96 tests
Fiche technique Fiche technique

HAP1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3131645
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3092885
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7409197
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits HAP1

Xiang, Yang, Xin, Gaertig, Reeves, Li, Li: "DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 7, pp. E1224-E1233, (2017) (PubMed).

Corradini, Burgers, Plank, Heck, Scholten: "Huntingtin-associated protein 1 (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP) specific for the cGMP-dependent protein kinase Iβ isoform." dans: The Journal of biological chemistry, Vol. 290, Issue 12, pp. 7887-96, (2015) (PubMed).

Corradini, Vallur, Raaijmakers, Feil, Feil, Heck, Scholten: "Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse." dans: Molecular & cellular proteomics : MCP, Vol. 13, Issue 8, pp. 2004-16, (2014) (PubMed).

Ma, Savas, Yu, Culver, Chao, Tanese: "Huntingtin mediates dendritic transport of ?-actin mRNA in rat neurons." dans: Scientific reports, Vol. 1, pp. 140, (2012) (PubMed).

Borrell-Pagès, Zala, Humbert, Saudou: "Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies." dans: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 22, pp. 2642-60, (2006) (PubMed).

Rong, McGuire, Fang, Sheng, Shin, Li, Li: "Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 22, pp. 6019-30, (2006) (PubMed).

Takeshita, Fujinaga, Zhao, Yanai, Shinoda: "Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis." dans: Human molecular genetics, Vol. 15, Issue 15, pp. 2298-312, (2006) (PubMed).

Gauthier, Charrin, Borrell-Pagès, Dompierre, Rangone, Cordelières, De Mey, MacDonald, Lessmann, Humbert, Saudou: "Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules." dans: Cell, Vol. 118, Issue 1, pp. 127-38, (2004) (PubMed).

Gutekunst, Torre, Sheng, Yi, Coleman, Riedel, Bujo: "Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 51, Issue 6, pp. 841-52, (2003) (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." dans: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à HAP1

huntingtin associated protein 1 (HAP1), huntingtin-associated protein 1 (Hap1), HAP-1, HAP1-A, HAP1-B, HAP2, hHLP1, HIP5, HLP

Protein level used designations for HAP1

  • HAP-1
  • huntingtin-associated protein 2
  • neuroan 1
  • huntingtin-associated protein 1 (neuroan 1)
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