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HAS2 Produits

(Hyaluronan Synthase 2 (HAS2))
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008].

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Catégories HAS2 en vedette

HAS2 Anticorps

High quality antibodies with extensive validation data.

HAS2 Kits ELISA

Reliable ELISA kits for a wide range of species.

HAS2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

HAS2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, WB, IHC, ICC
Validations
  • (2)
  • (5)
N° du produit ABIN1098124
Quantité 0.1 mg
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, FACS, IHC (p)
Validations
  • (2)
  • (4)
N° du produit ABIN651874
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IF
Validations
  • (1)
N° du produit ABIN7155956
Quantité 100 μg
Fiche technique Fiche technique

HAS2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6967475
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956614
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1137607
Quantité 96 tests
Fiche technique Fiche technique

HAS2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1306364
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3081633
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3120959
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits HAS2

Wang, Zhou, Wang, Liu, Chen, Jiang, Luo, Stupack, Luo: "Role of Hyaluronan and Glucose on 4-Methylumbelliferone-inhibited Cell Proliferation in Breast Carcinoma Cells." dans: Anticancer research, Vol. 35, Issue 9, pp. 4799-805, (2016) (PubMed).

Lien, Lee, Jeng, Lin, Lu, Yao: "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance." dans: Histopathology, Vol. 65, Issue 3, pp. 328-39, (2015) (PubMed).

Zhu, Deng, Huang, Wang, Yang, Chen, Ma, Wang: "A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect." dans: PLoS ONE, Vol. 9, Issue 2, pp. e87437, (2014) (PubMed).

Kobayashi, Banno, Shimizu, Ueki, Tsuji, Masuda, Kisu, Nomura, Tominaga, Nagano, Saya, Aoki: "Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta." dans: Placenta, Vol. 34, Issue 2, pp. 110-8, (2013) (PubMed).

Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." dans: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).

Jokela, Makkonen, Oikari, Kärnä, Koli, Hart, Tammi, Carlberg, Tammi: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." dans: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, (2011) (PubMed).

Synonymes et noms alternatifs relatifs à HAS2

hyaluronan synthase 2 (has2), hyaluronan synthase 2 (HAS2), hyaluronan synthase 2 (Has2), hyaluronan synthase 2 (SHAS2), hyaluronan synthase 2 S homeolog (has2.S), DG42, Has2, XHas2

Protein level used designations for HAS2

  • hyaluronan synthase 2
  • hyaluronic acid synthase 2
  • HA synthase 2
  • hyaluronan synthase homolog
  • hyaluronate synthase 2
  • CHAS2
  • xHAS2
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