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HLA-DQB1 Produits

(Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))

Catégories

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].

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Catégories HLA-DQB1 en vedette

HLA-DQB1 Anticorps

High quality antibodies with extensive validation data.

HLA-DQB1 Kits ELISA

Reliable ELISA kits for a wide range of species.

HLA-DQB1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

HLA-DQB1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
N° du produit ABIN7155597
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS
Validations
  • (4)
N° du produit ABIN1327606
Quantité 50 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (4)
  • (1)
N° du produit ABIN1881422
Quantité 400 μL
Fiche technique Fiche technique

HLA-DQB1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6957623
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6957624
Quantité 96 tests
Fiche technique Fiche technique

HLA-DQB1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1306761
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1306759
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3092196
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits HLA-DQB1

Sillé, Conde, Zhang, Akers, Sanchez, Maltbaek, Riby, Smith, Skibola: "Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression." dans: Genes and immunity, Vol. 15, Issue 2, pp. 133-6, (2014) (PubMed).

Larhammar, Hyldig-Nielsen, Servenius, Andersson, Rask, Peterson: "Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 23, pp. 7313-7, (1984) (PubMed).

Boss, Strominger: "Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 16, pp. 5199-203, (1984) (PubMed).

Larhammar, Andersson, Andersson, Bill, Böhme, Claesson, Denaro, Emmoth, Gustafsson, Hammarling: "Molecular analysis of human class II transplantation antigens and their genes." dans: Human immunology, Vol. 8, Issue 1, pp. 95-103, (1983) (PubMed).

Larhammar, Schenning, Gustafsson, Wiman, Claesson, Rask, Peterson: "Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, Issue 12, pp. 3687-91, (1982) (PubMed).

Synonymes et noms alternatifs relatifs à HLA-DQB1

major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), major histocompatibility complex, class II, DQ beta 1 (PATR-DQB1), major histocompatibility complex, class II, DQ beta 1 (DLA-DQB1), major histocompatibility complex, class II, DQ beta 1 (MAMU-DQB1), major histocompatibility complex, class II, DQ beta 1 (LOC100172120), CELIAC1, DKFZp469C0237, DLA-DQB, HLA-DQB, IDDM1, LOC100172120, MAMU-DQB1, mhc-DRB

Protein level used designations for HLA-DQB1

  • HLA class II histocompatibility antigen, DQ beta 1 chain
  • MHC DQ beta
  • MHC class II DQ beta chain
  • MHC class II HLA-DQ beta glycoprotein
  • MHC class II antigen DQB1
  • MHC class II antigen HLA-DQ-beta-1
  • MHC class2 antigen
  • lymphocyte antigen
  • MHC class II DRB antigen
  • MHC class II DLA DQ beta chain
  • major histocompatibility complex, class II, DQ beta 1
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