The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008].
IL2
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
IL2
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Stepanova, Sinkora: "Porcine ?? T lymphocytes can be categorized into two functionally and developmentally distinct subsets according to expression of CD2 and level of TCR." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 5, pp. 2111-20, (2013) (PubMed).
Webster, Zufferey, Pane, Coulson: "Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice." dans: PLoS ONE, Vol. 8, Issue 3, pp. e59182, (2013) (PubMed).
Stěpánová, Sinkora: "The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs." dans: Developmental and comparative immunology, Vol. 36, Issue 4, pp. 728-40, (2012) (PubMed).
Phuan, Ratelade, Rossi, Tradtrantip, Verkman: "Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays." dans: The Journal of biological chemistry, Vol. 287, Issue 17, pp. 13829-39, (2012) (PubMed).
Suzuki, Jagger, Konya, Shimojima, Pryshchep, Goronzy, Weyand: "CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2118-30, (2012) (PubMed).