IL12B Protéines
(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
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IL12B
Origine: Cynomolgus
Hôte: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
IL12B
Origine: Souris
Hôte: Human Cells
Recombinant
> 95 % as determined by SDS-PAGE
1 image
IL12B
Origine: Humain
Hôte: Wheat germ
Recombinant
WB, ELISA, AP, AA
1 image
IL12B
Origine: Humain
Hôte: Baculovirus infected Insect Cells
Recombinant
> 90 %
SDS
1 image
IL12B
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
1 image
IL12B
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
90 %
ELISA
1 image
3 références
IL12B
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
IL12B
Origine: Mouton
Hôte: Levure
Recombinant
> 90 %
ELISA
IL12B
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
IL12B
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 98 %
CC
Active
IL12B
Origine: Souris
Hôte: Escherichia coli (E. coli)
Recombinant
> 98 %
CC
Active
IL12B
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 97 % by SDS-PAGE.
Active
IL12B
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
IL12B
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 %
WB, Ct
IL12B
Origine: Humain
Hôte: Mammalian Cells
Recombinant
Greater than 90 % as determined by SDS-PAGE.
WB, ELISA
IL12B
Origine: Souris
Hôte: Mammalian Cells
Recombinant
Greater than 95 % as determined by SDS-PAGE.
WB, ELISA
IL12B
Origine: Rat
Hôte: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
IL12B
Origine: Souris
Hôte: Mammalian Cells
Recombinant
>90 % as determined by SDS-PAGE.
WB, SDS, Imm, ELISA, AcA
Active
IL12B
Origine: Humain
Hôte: Mammalian Cells
Recombinant
>90 % as determined by SDS-PAGE.
WB, SDS, Imm, ELISA, AcA
Active
Dernières publications pour nos IL12B Protéines
: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." dans: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." dans: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." dans: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." dans: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." dans: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
Pseudonymes pour IL12B Protéines
interleukin 12B (IL12B) Protéinesinterleukin 12b (Il12b) Protéines
interleukin 12B (Il12b) Protéines
interleukin 12Ba (il12ba) Protéines
CLMF Protéines
CLMF2 Protéines
CLMF p40 Protéines
IL-12 Protéines
IL-12 p40 Protéines
IL-12.p40 Protéines
IL-12B Protéines
Il-12b Protéines
Il-12p40 Protéines
IL-12p40 Protéines
Il12 Protéines
il12b Protéines
IL12B Protéines
Il12p40 Protéines
IL12p40 Protéines
il12p40.b Protéines
NKSF Protéines
NKSF2 Protéines
p40 Protéines
zgc:152789 Protéines
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