IL12B Protéines
(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| IL12B Protein (AA 23-328) (His tag) | Cynomolgus | HEK-293 Cells |
|
463,21 €
Voir le prix
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| IL12B Protein (AA 23-328) (His tag) | Humain | HEK-293 Cells |
|
988,62 €
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|
|
| IL12B Protein (AA 23-328) (His tag) | Humain | Baculovirus infected Insect Cells |
|
907,69 €
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|
|
| IL12B Protein (AA 23-328, full length) (His tag) | Humain | Mammalian Cells |
|
378,40 €
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|
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| IL12B Protein (AA 229-328) (GST tag) | Humain | Wheat germ |
|
624,00 €
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| IL12B Protein (AA 23-335) (His tag) | Souris | HEK-293 Cells |
|
287,60 €
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|
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| IL12B Protein (AA 23-335) (His tag) | Souris | Mammalian Cells |
|
731,38 €
Voir le prix
|
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| IL12B Protein (AA 23-328) (His tag) | Humain | Mammalian Cells |
|
731,38 €
Voir le prix
|
|
| IL12B Protein (AA 23-328) (His tag) | Humain | Escherichia coli (E. coli) |
|
478,03 €
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|
|
| IL12B Protein (AA 23-328) (His tag) | Humain | HEK-293 Cells |
|
230,69 €
Voir le prix
|
|
| IL12B Protein (His tag) | Souris | HEK-293 Cells |
|
325,00 €
Voir le prix
|
|
| IL12B Protein (His tag) | Humain | HEK-293 Cells |
|
1.870,00 €
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|
|
| IL12B Protéine | Souris | HEK-293 Cells |
|
415,00 €
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|
|
| IL12B Protein (His tag) | Souris | Escherichia coli (E. coli) |
|
278,46 €
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|
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| IL12B Protéine | Humain | Hi-5 Cells |
|
1.004,17 €
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|
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| IL12B Protein (AA 23-335) (His tag) | Souris | Mammalian Cells |
|
486,15 €
Voir le prix
|
|
| IL12B Protein (AA 23-328) | Humain | Mammalian Cells |
|
486,15 €
Voir le prix
|
|
| IL12B Protein (AA 23-329) (His tag) | Chien | Escherichia coli (E. coli) |
|
794,22 €
Voir le prix
|
|
| IL12B Protein (AA 23-327) (His tag) | Boeuf (Vache) | Escherichia coli (E. coli) |
|
821,88 €
Voir le prix
|
|
| IL12B Protein (AA 30-320) (His tag) | Humain | Escherichia coli (E. coli) |
|
837,14 €
Voir le prix
|
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Cynomolgus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- ScA (Screening Assay: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- SDS (SDS-PAGE: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Origine
- Humain
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- Greater than 95 % as determined by SDS-PAGE.
Protein
- AP (Affinity Purification: Application indiquée)
- AA (Antibody Array: Application indiquée)
- ELISA (ELISA: Application indiquée)
- WB (Western Blotting: Application indiquée)
- Origine
- Humain
- Hôte
- Wheat germ
- Type Proteine
- Recombinant
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- ELISA (ELISA: Application indiquée)
- AcA (Activity Assay: Application indiquée)
- Origine
- Souris
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- ELISA (ELISA: Application indiquée)
- AcA (Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Application indiquée)
- PC (Positive Control: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 95 %
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
Protein
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 97 % by SDS-PAGE.
- Activité biologique
- Active
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % by SDS-PAGE.
- Activité biologique
- Active
Protein
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 92 % by SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Application indiquée)
- Origine
- Souris
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- >98 %
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Application indiquée)
- Origine
- Humain
- Hôte
- Hi-5 Cells
- Type Proteine
- Recombinant
- Pureté
- > 90 % pure
Protein
- WB (Western Blotting: Application indiquée)
- ELISA (ELISA: Application indiquée)
- Origine
- Souris
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- Greater than 95 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: Application indiquée)
- ELISA (ELISA: Application indiquée)
- Origine
- Humain
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- PC (Positive Control: Application indiquée)
- Origine
- Chien
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 97 %
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- PC (Positive Control: Application indiquée)
- Origine
- Boeuf (Vache)
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 97 %
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- PC (Positive Control: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 97 %
Dernières publications pour nos IL12B Protéines
: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." dans: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).
: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." dans: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." dans: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." dans: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." dans: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." dans: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." dans: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." dans: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." dans: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
Pseudonymes pour IL12B Protéines
interleukin 12B (IL12B) Protéinesinterleukin 12b (Il12b) Protéines
interleukin 12B (Il12b) Protéines
interleukin 12Ba (il12ba) Protéines
CLMF Protéines
CLMF2 Protéines
CLMF p40 Protéines
IL-12 Protéines
IL-12 p40 Protéines
IL-12.p40 Protéines
IL-12B Protéines
Il-12b Protéines
Il-12p40 Protéines
IL-12p40 Protéines
Il12 Protéines
il12b Protéines
IL12B Protéines
Il12p40 Protéines
IL12p40 Protéines
il12p40.b Protéines
NKSF Protéines
NKSF2 Protéines
p40 Protéines
zgc:152789 Protéines
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