IL12RB2 Produits
(Interleukin 12 Receptor, beta 2 (IL12RB2))
Catégories
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012].
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Catégories IL12RB2 en vedette
IL12RB2 Anticorps
High quality antibodies with extensive validation data.
IL12RB2 Kits ELISA
Reliable ELISA kits for a wide range of species.
IL12RB2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
IL12RB2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (5)
N° du produit
ABIN747878
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC, ELISA
Validations
- (2)
N° du produit
ABIN7239068
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, FACS, IHC (p)
Validations
- (2)
N° du produit
ABIN1904911
Quantité
200 μL
Fiche technique
Fiche technique
IL12RB2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957019
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730312
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4883298
Quantité
96 tests
Fiche technique
Fiche technique
IL12RB2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
Human Cells
Validations
- (1)
N° du produit
ABIN7320555
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307683
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307682
Quantité
25 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits IL12RB2
: "POSH Regulates CD4+ T Cell Differentiation and Survival." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 10, pp. 4003-13, (2016) (PubMed).: "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue." dans: Acta neuropathologica communications, Vol. 4, Issue 1, pp. 100, (2016) (PubMed).
: "Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata." dans: Frontiers in pharmacology, Vol. 7, pp. 386, (2016) (PubMed).
: "Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis." dans: Cytokine, Vol. 73, Issue 1, pp. 36-43, (2015) (PubMed).
: "Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions." dans: Journal of virology, Vol. 88, Issue 13, pp. 7474-84, (2014) (PubMed).
: "Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages." dans: Nature immunology, Vol. 12, Issue 6, pp. 551-9, (2011) (PubMed).
: "Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 12, pp. 6165-72, (2002) (PubMed).
: "Differentiation of murine NK cells into distinct subsets based on variable expression of the IL-12R beta 2 subunit." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 4985-93, (2000) (PubMed).
: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, (2000) (PubMed).
: "Role of IL-12 in intrathymic negative selection." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4349-59, (1999) (PubMed).
Synonymes et noms alternatifs relatifs à IL12RB2
interleukin 12 receptor subunit beta 2 (IL12RB2), interleukin 12 receptor, beta 2 (Il12rb2), interleukin 12 receptor subunit beta 2 (Il12rb2), A930027I18Rik, Ifnm, IL-12RB2, IL12RB2Protein level used designations for IL12RB2
- interleukin 12 receptor, beta 2
- interleukin 12 receptor beta-2
- interleukin-12 receptor subunit beta-2
- interleukin-12 receptor subunit beta-2-like
- IL-12 receptor subunit beta-2
- IL-12R subunit beta-2
- IL-12R-beta-2
- interferon response to microorganisms
- interleukin-12 receptor beta-2 chain
- IL-12RB2
- interleukin-12 receptor beta 2
- IL-12 receptor beta-2
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