This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
KITLG
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos KIT Ligand Protéines
Turnis, Kaminska, Smith, Kartchner, Vogel, Laxton, Ashmun, Ney, Opferman: "Requirement for antiapoptotic MCL-1 during early erythropoiesis." dans: Blood, Vol. 137, Issue 14, pp. 1945-1958, (2021) (PubMed).
Vas, Wandhoff, Dörr, Niebel, Geiger: "Contribution of an aged microenvironment to aging-associated myeloproliferative disease." dans: PLoS ONE, Vol. 7, Issue 2, pp. e31523, (2012) (PubMed).
Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." dans: Blood, Vol. 118, Issue 3, pp. 565-75, (2011) (PubMed).
Perry, He, Sugimura, Grindley, Haug, Ding, Li: "Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion." dans: Genes & development, Vol. 25, Issue 18, pp. 1928-42, (2011) (PubMed).
Herraiz, Journé, Abdel-Malek, Ghanem, Jiménez-Cervantes, García-Borrón: "Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT." dans: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 1, pp. 138-56, (2011) (PubMed).
Woost, Solchaga, Meyerson, Shankey, Goolsby, Jacobberger: "High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow." dans: Blood, Vol. 117, Issue 15, pp. e131-41, (2011) (PubMed).
Fukuda, Bian, King, Pelus: "The chemokine GRObeta mobilizes early hematopoietic stem cells characterized by enhanced homing and engraftment." dans: Blood, Vol. 110, Issue 3, pp. 860-9, (2007) (PubMed).