KIT Ligand Protein (KITLG) (AA 26-189) (His tag)

N° du produit ABIN7321261

Protéine Recombinant KIT Ligand exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour KIT Ligand Protein (KITLG) (AA 26-189) (His tag) (ABIN7321261)

Antigène: KIT Ligand (KITLG)

Type de proteíne: Recombinant

Origine: Rat

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 26-189

Purification/Conjugué: Cette KIT Ligand protéine est marqué à la His tag.

Fonction: Recombinant Rat SCF/c-Kit Ligand Protein (E.coli, His Tag)

Séquence: Gln26-Ala189

Attributs du produit: Recombinant Rat Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: KIT Ligand (KITLG)

Autre désignation: SCF/c-Kit Ligand

Sujet: FPH2,KIT ligand,KITLG,KL-1,Kitl,MGF,MGFSHEP7,Mast cell growth factor,SCF,SFc-Kit ligand,SLF,Stem Cell Factor,c-kit Ligand,steel factor,Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

Poids moléculaire:

Calculated MW: 19.3 kDa

Observed MW: 18 kDa

ID gène: 60427

UniProt: P21581

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway