SNCA Kit ELISA

N° du produit ABIN1059104

Détail du produit SNCA Kit ELISA

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Analytical Method: Quantitative

Attributs du produit: This ELISA assay kit provides a standard peptide solution with known concentration to calibrate absorbance readings to concentration.

Ingrédients: Store all materials at 4 °C:

• Standard peptide: 0.5 mL
• Standard diluent: 1.5 mL
• Microelisa Strip plate: 12 well x 8 strips
• 6 mL HRP-Conjugate Antibody
• 30 x wash solution with 25 mL
• 5 mL Sample diluent
• 5 mL Chromogen Solution A
• 5 mL Chromogen Solution B
• 5 mL Stop Solution
• Instruction Manual
• 2 Closure plate membrane
• Sealed bag

Matériel non inclus:

• 37 °C incubator
• Standard absorbance microplate reader
• Precision pipettes and disposable pipette tips
• De-ionized water
• Disposable tubes for sample dilution
• Absorbent paper

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour SNCA Kit ELISA (ABIN1059104)

Johnson, Drugan, Miller, Evans: "38" dans: , Vol. 1363, Issue Nucleic acids research, pp. 28-39, (1991)

Détail du antigène

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: alpha-Synuclein (SNCA Produits)

Synonymes: snca Kit ELISA, MGC64356 Kit ELISA, LOC619283 Kit ELISA, NACP Kit ELISA, alphaSYN Kit ELISA, PARK1 Kit ELISA, PARK4 Kit ELISA, PD1 Kit ELISA, synuclein alpha L homeolog Kit ELISA, alpha-synuclein Kit ELISA, synuclein alpha Kit ELISA, synuclein, alpha Kit ELISA, snca.L Kit ELISA, LOC619283 Kit ELISA, SNCA Kit ELISA, Snca Kit ELISA

Sujet: Alpha-synuclein (SNCA gene) is a 140 amino acid predominantly cytosolic protein expressed in brain associated with fibrillar structures in Lewy Bodies. Although primary located in the cytosol, alpha-synuclein binds to phospholipid and may assemble into pore-like structures in cellular membranes. Generation of aggregates in Lewy Bodies and/or association of alpha-synuclein with membraneous structures have been attributed to the etiology of Parkinson's Disease. Many additional cellular mechanisms associated with abnormal accumulations of alpha-synuclein in brain have also been proposed as underlying etiologies of the disease.
Parkinson's disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features of the disease include the characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies in brain and spinal cord.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity