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Growth Hormone Receptor Kit ELISA

GHR Reactivité: Humain AA 27-264 Colorimetric Sandwich ELISA
N° du produit ABIN5510646
  • Antigène Voir toutes Growth Hormone Receptor (GHR) Kits ELISA
    Growth Hormone Receptor (GHR)
    Épitope
    AA 27-264
    Reactivité
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Application
    ELISA
    Fonction
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human GHR
    Marque
    PicoKine™
    Analytical Method
    Quantitative
    Specificité
    Expression system for standard: NSO
    Immunogen sequence: A27-Y264
    Réactivité croisée (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Attributs du produit

    Tissue Specificity: Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.

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  • Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Date de péremption
    12 months
  • Antigène Voir toutes Growth Hormone Receptor (GHR) Kits ELISA
    Growth Hormone Receptor (GHR)
    Autre désignation
    GHR (GHR Produits)
    Synonymes
    GHBP Kit ELISA, AA986417 Kit ELISA, GHR/BP Kit ELISA, GHR Kit ELISA, ghr Kit ELISA, ghr.a Kit ELISA, zgc:162141 Kit ELISA, growth hormone receptor Kit ELISA, growth hormone receptor L homeolog Kit ELISA, growth hormone receptor a Kit ELISA, GHR Kit ELISA, Ghr Kit ELISA, ghr.L Kit ELISA, ghr Kit ELISA, ghra Kit ELISA
    Sujet

    Protein Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). .

    Background: Growth hormone receptor is a protein that in humans is encoded by the GHR gene. It is mapped to chromosome 5p13.1-p12. This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization (the receptor may however also exist as a pre-assembled non-functional dimer) and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism).

    Synonyms: Growth hormone receptor,GH receptor,Somatotropin receptor,Growth hormone-binding protein,GH-binding protein,GHBP,Serum-binding protein,GHR,

    Full Gene Name: Growth hormone receptor

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway..
    UniProt
    P10912
    Pathways
    Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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