KIT Kit ELISA

N° du produit ABIN5510737

Détail du produit KIT Kit ELISA

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Épitope: AA 25-527

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse CD117/c-kit

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: S25-P527

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: Kit (KIT Produits)

Synonymes: C-Kit Kit ELISA, CD117 Kit ELISA, PBT Kit ELISA, SCFR Kit ELISA, Bs Kit ELISA, Fdc Kit ELISA, Gsfsco1 Kit ELISA, Gsfsco5 Kit ELISA, Gsfsow3 Kit ELISA, SCO1 Kit ELISA, SCO5 Kit ELISA, SOW3 Kit ELISA, Ssm Kit ELISA, Tr-kit Kit ELISA, W Kit ELISA, c-KIT Kit ELISA, c-kit Kit ELISA, MGF Kit ELISA, KIT Kit ELISA, C-KIT Kit ELISA, kit Kit ELISA, receptor Kit ELISA, sparse Kit ELISA, Xkl-1 Kit ELISA, kit-a Kit ELISA, kit-b Kit ELISA, kl1-A Kit ELISA, krk1 Kit ELISA, pbt Kit ELISA, scfr Kit ELISA, KIT proto-oncogene receptor tyrosine kinase Kit ELISA, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a Kit ELISA, KIT proto-oncogene receptor tyrosine kinase S homeolog Kit ELISA, KIT Kit ELISA, Kit Kit ELISA, kita Kit ELISA, kit Kit ELISA, kit.S Kit ELISA

Sujet:

Protein Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. .

Background: SCFR(Mast/stem cell growth factor receptor), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a protein that in humans is encoded by the KIT gene. KIT was first described as the cellular homolog of the feline sarcoma viral oncogene v-kit. The KIT gene is mapped on 4q12. Kit was expressed on the surface of germ cells up to the pachytene stage. Signaling from the KIT receptor tyrosine kinase is essential for primordial germ cell growth both in vivo and in vitro. Determination of the KIT effectors acting in primordial germ cells has been hampered by the lack of effective methods to manipulate easily gene expression in these cells.

Synonyms: Mast/stem cell growth factor receptor Kit,SCFR,2.7.10.1,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,CD117,Kit,Sl,

Full Gene Name: Mast/stem cell growth factor receptor Kit

Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein.

UniProt: P05532

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity