KLRK1 Produits
(Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
Catégories
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010].
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Catégories KLRK1 en vedette
KLRK1 Anticorps
High quality antibodies with extensive validation data.
KLRK1 Kits ELISA
Reliable ELISA kits for a wide range of species.
KLRK1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
KLRK1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, ELISA
Validations
- (6)
N° du produit
ABIN7193627
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
FACS
Validations
- (7)
- (4)
N° du produit
ABIN1027688
Quantité
100 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, FACS, ELISA, IHC (fro), IF (cc), IF (p), IHC (p)
Validations
- (3)
- (4)
N° du produit
ABIN730078
Quantité
100 μL
Fiche technique
Fiche technique
KLRK1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730443
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4882179
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6385461
Quantité
96 tests
Fiche technique
Fiche technique
KLRK1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (6)
N° du produit
ABIN7275337
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7275342
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7275334
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits KLRK1
: "Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis." dans: RNA biology, Vol. 16, Issue 11, pp. 1592-1603, (2019) (PubMed).: "Quantitative and functional analysis of CD69(+) T regulatory lymphocytes in patients with periodontal disease." dans: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, (2016) (PubMed).
: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." dans: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).
: "NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma." dans: Oncotarget, Vol. 7, Issue 42, pp. 68513-68526, (2016) (PubMed).
: "A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease." dans: Infection, Vol. 43, Issue 3, pp. 353-9, (2015) (PubMed).
: "Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain." dans: BMC cancer, Vol. 15, pp. 1011, (2015) (PubMed).
: "Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human ..." dans: PLoS pathogens, Vol. 11, Issue 3, pp. e1004671, (2015) (PubMed).
: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." dans: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).
: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." dans: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).
: "NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure." dans: PLoS ONE, Vol. 10, Issue 8, pp. e0134568, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à KLRK1
killer cell lectin like receptor K1 (KLRK1), killer cell lectin-like receptor subfamily K, member 1 (KLRK1), killer cell lectin-like receptor subfamily K, member 1 (Klrk1), killer cell lectin like receptor K1 (Klrk1), NKG2D protein (NKG2D), CD314, D6H12S2489E, D12S2489E, KLR, KLRK1, NKG2-D, NKG2D, Nkg2d, Nkrp2Protein level used designations for KLRK1
- killer cell lectin-like receptor subfamily K, member 1
- NKG2-D type II integral membrane protein-like
- NK cell receptor D
- NKG2-D type II integral membrane protein
- NKG2-D-activating NK receptor
- natural killer cell group 2D
- NK lectin-like receptor
- NKLLR
- NKR-P2, ortholog of human NKG2D
- killer cell lectin-like receptor subfamily K member 1
- NKG2-D activating NK receptor
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