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KLRC1 Produits

(Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Catégories KLRC1 en vedette

KLRC1 Anticorps

High quality antibodies with extensive validation data.

KLRC1 Kits ELISA

Reliable ELISA kits for a wide range of species.

KLRC1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

KLRC1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF, FACS, IHC (p)
Validations
  • (6)
N° du produit ABIN652569
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
N° du produit ABIN7161640
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (3)
N° du produit ABIN517356
Quantité 100 μg
Fiche technique Fiche technique

KLRC1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6730533
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6730532
Quantité 96 tests
Fiche technique Fiche technique

KLRC1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
N° du produit ABIN7275339
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
N° du produit ABIN7275338
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275335
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits KLRC1

Ojo, Sharma, Liu, Moreton, Checkley-Luttge, Gupta, Lee, Lee, Otegbeye, Sekaly, de Lima, Wald: "Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells." dans: Scientific reports, Vol. 9, Issue 1, pp. 14916, (2019) (PubMed).

Zou, Zuo, Yang, Fan: "The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells." dans: Biochemical and biophysical research communications, Vol. 478, Issue 1, pp. 213-20, (2016) (PubMed).

Gill, Peppa, Micco, Singh, Carey, Foster, Maini, Kennedy: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." dans: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).

Loyon, Picard, Mauvais, Queiroz, Mougey, Pallandre, Galaine, Mercier-Letondal, Kellerman, Chaput, Wijdenes, Adotévi, Ferrand, Romero, Godet, Borg: "IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 1, pp. 85-96, (2016) (PubMed).

Guo, Shen, Fu, Liu, Chen, Ni, Ye, Sun, Li, Tian, Wei: "CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients." dans: Scientific reports, Vol. 6, pp. 25567, (2016) (PubMed).

Kruse, Hamann, Monecke, Cyganek, Elsner, Hübscher, Walter, Streckfuss-Bömeke, Guan, Dressel: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." dans: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).

Roberti, Juliá, Rocca, Amat, Bravo, Loza, Coló, Loza, Fabiano, Maino, Podhorzer, Fainboim, Barrio, Mordoh, Levy: "Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade." dans: European journal of immunology, Vol. 45, Issue 5, pp. 1560-9, (2015) (PubMed).

Zhao, Xu, Dai, Peng, Zhu, Shen, Zheng, Ran: "WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features." dans: BMC gastroenterology, Vol. 15, pp. 173, (2015) (PubMed).

Spallanzani, Torres, Avila, Ziblat, Iraolagoitia, Rossi, Domaica, Fuertes, Rabinovich, Zwirner: "Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 5, pp. 2141-8, (2015) (PubMed).

Picardi, Mengarelli, Marino, Gallo, Benevolo, Pescarmona, Cocco, Fraioli, Tremante, Petti, De Fabritiis, Giacomini: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." dans: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à KLRC1

killer cell lectin like receptor C1 (Klrc1), killer cell lectin like receptor C1 (KLRC1), NKG2-A/NKG2-B type II integral membrane protein-like (NKG2A), killer cell lectin-like receptor subfamily C, member 3 (KLRC3), killer cell lectin-like receptor subfamily C, member 1 (KLRC1), killer cell lectin-like receptor subfamily C, member 1 (Klrc1), CD159A, CD159a, KLRC1, NKG2, NKG2-A, NKG2A, NKG2B, rNKG2A

Protein level used designations for KLRC1

  • natural killer cell protein group 2-A (NKG2A)
  • CD159 antigen-like family member A
  • NK cell receptor A
  • NKG2-A/B-activating NK receptor
  • NKG2-A/NKG2-B type II integral membrane protein
  • killer cell lectin-like receptor subfamily C, member 1
  • C-lectin type II protein
  • NKG2-1/B activating NK receptor
  • NKG2-A/B type II integral membrane protein
  • natural killer cell lectin
  • natural killer group protein 2
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