LIMK2 Produits
(LIM Domain Kinase 2 (LIMK2))
Catégories
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories LIMK2 en vedette
LIMK2 Anticorps
High quality antibodies with extensive validation data.
LIMK2 Kits ELISA
Reliable ELISA kits for a wide range of species.
LIMK2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LIMK2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (10)
N° du produit
ABIN6256239
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
N° du produit
ABIN561676
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (3)
N° du produit
ABIN7138860
Quantité
100 μL
Fiche technique
Fiche technique
LIMK2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN5592316
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN2870021
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Cow
Analytical Method
Validations
N° du produit
ABIN2870017
Quantité
96 tests
Fiche technique
Fiche technique
LIMK2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
N° du produit
ABIN5570605
Quantité
5 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309440
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309442
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LIMK2
: "LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission." dans: Cell death and differentiation, Vol. 21, Issue 7, pp. 1036-49, (2014) (PubMed).: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." dans: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin." dans: The EMBO journal, Vol. 24, Issue 3, pp. 473-86, (2005) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." dans: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." dans: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop." dans: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3577-82, (2000) (PubMed).
: "The RET proto-oncogene in human cancers." dans: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics." dans: Nature cell biology, Vol. 1, Issue 5, pp. 253-9, (1999) (PubMed).
Synonymes et noms alternatifs relatifs à LIMK2
LIM domain kinase 2 L homeolog (limk2.L), LIM domain kinase 2 (limk2), LIM domain kinase 2 (LIMK2), LIM domain kinase 2 (Limk2), LIM motif-containing protein kinase 2 (Limk2), 9430059K01, A930024P04Rik, C85310, LIMK, LIMK2, Limk2a, Limk2b, Link2, wu:fa97c09, wu:fk73e11, xlimk2, zgc:91990Protein level used designations for LIMK2
- XLIM-Kinases2
- LIM domain kinase 2
- LIM domain kinase 2-like
- LIM motif-containing protein kinase 2
- LIMK-2
- LIM kinase 2
- LIM-containing protein kinase 2a
- LIM-containing protein kinase 2t
- Limk2t-1 and Limk2t-2
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