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LRP6 Protéines

(Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].

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LRP6 Protein (AA 20-630) (mFc Tag)

LRP6 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE

Human LRP-6 on Tris-Bis PAGE under reduced condition.

SDS

SEC-HPLC

Immobilized Human DKK1, His Tag at 5 μg/mL (100 μL/Well) on the plate.

ELISA

3 images

N° du produit ABIN7275210

Détails

LRP6 Protein (AA 20-1370) (His tag)

LRP6 Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.