LRP6 Protein (AA 20-630) (His-Avi Tag,Biotin)
-
- Antigène Voir toutes LRP6 Protéines
- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 20-630
-
Origine
- Humain
-
Source
- HEK-293 Cells
- Purification/Conjugué
- Cette LRP6 protéine est marqué à la His-Avi Tag,Biotin.
- Fonction
- Biotinylated Human LRP-6 (20-630) Protein, His,Avitag™
- Séquence
- Ala 20 - Pro 630
- Attributs du produit
- Biotinylated Human LRP-6, His,Avitag (LR6-H82E7) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 630 (Accession # O75581-1 ).
- Pureté
- >90 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product LRP6 Protéine
-
-
- Indications d'application
- This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 72.5 kDa. The protein migrates as 80-100 kDa under reducing (R) condition due to glycosylation.
- Commentaires
-
Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.
This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled. - Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
- Stockage commentaire
- -20°C
-
- Antigène
- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
- Autre désignation
- LRP-6 (LRP6 Produits)
- Synonymes
- lrp6-A Protein, Xlrp6 Protein, adcad2 Protein, lrp6 Protein, LRP6 Protein, ADCAD2 Protein, C030016K15Rik Protein, Cd Protein, Gw Protein, LDL receptor related protein 6 Protein, LDL receptor related protein 6 L homeolog Protein, LDL receptor related protein 6 S homeolog Protein, low density lipoprotein receptor-related protein 6 Protein, low-density lipoprotein receptor-related protein 6 Protein, LRP6 Protein, lrp6.L Protein, lrp6.S Protein, lrp6 Protein, Lrp6 Protein, LOC590395 Protein
- Sujet
-
Synonyms: LRP-6,LRP6,
Description: LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. - Poids moléculaire
- 72.5 kDa
- NCBI Accession
- NP_002327
- Pathways
- Signalisation WNT, Tube Formation
-