MANF Produits
(Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
Catégories
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010].
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Catégories MANF en vedette
MANF Anticorps
High quality antibodies with extensive validation data.
MANF Kits ELISA
Reliable ELISA kits for a wide range of species.
MANF Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MANF recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (7)
N° du produit
ABIN6143461
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
N° du produit
ABIN7426499
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, IHC (p)
Validations
- (3)
N° du produit
ABIN6990751
Quantité
0.1 mg
Fiche technique
Fiche technique
MANF recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
N° du produit
ABIN6957758
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6957759
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957760
Quantité
96 tests
Fiche technique
Fiche technique
MANF recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
N° du produit
ABIN5509524
Quantité
40 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123914
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1345666
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MANF
: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." dans: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).: "Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice." dans: Neurobiology of disease, Vol. 134, pp. 104696, (2020) (PubMed).
: "MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System." dans: eNeuro, Vol. 7, Issue 1, (2020) (PubMed).
: "MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex." dans: eNeuro, Vol. 4, Issue 5, (2018) (PubMed).
: "Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance." dans: Endocrine journal, Vol. 64, Issue 4, pp. 403-410, (2017) (PubMed).
: "Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling." dans: The Journal of steroid biochemistry and molecular biology, Vol. 171, pp. 94-109, (2017) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." dans: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing." dans: PLoS ONE, Vol. 7, Issue 6, pp. e39359, (2012) (PubMed).
: "MANF regulates dopaminergic neuron development in larval zebrafish." dans: Developmental biology, Vol. 370, Issue 2, pp. 237-49, (2012) (PubMed).
: "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." dans: Nature, Vol. 448, Issue 7149, pp. 73-7, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à MANF
mesencephalic astrocyte derived neurotrophic factor (MANF), mesencephalic astrocyte-derived neurotrophic factor (Manf), RNA binding motif protein 15B (RBM15B), Mesencephalic astrocyte-derived neurotrophic factor (Manf), mesencephalic astrocyte-derived neurotrophic factor (manf), mesencephalic astrocyte derived neurotrophic factor (Manf), mesencephalic astrocyte-derived neurotrophic factor S homeolog (manf.S), 3230402M22Rik, AA407711, AA408789, AA673178, anon-EST:ParkEST188, ARMET, Armet, armet, ARP, arp, ARP-like, CG7013, D18Mgi17, D17914, Dmel\\CG7013, DmMANF, im:6909481, MANF, manf, RBM15B, zgc:153327Protein level used designations for MANF
- arginine-rich, mutated in early stage tumors
- arginine-rich protein
- mesencephalic astrocyte-derived neurotrophic factor
- RNA binding motif protein 15B
- chromosome 3p21.1 gene sequence
- CG7013-PA
- Manf-PA
- ARP-like
- LOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor
- mesencephalic astrocyte-derived neurotrophic factor S homeolog
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