+49 (0)241 95 163 153
+49 (0)241 95 163 155

MANF Protein (His tag)

MANF Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
N° du produit ABIN7320099
  • Antigène Voir toutes MANF Protéines
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Type de proteíne
    • 11
    • 1
    • 1
    • 1
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Cette MANF protéine est marqué à la His tag.
    Recombinant Mouse MANF/ARMET Protein (His Tag)
    Met 1-Leu 179
    Attributs du produit
    A DNA sequence encoding the mouse MANF (NP_083379.2) (Met 1-Leu 179) was expressed, with a C-terminal polyhistidine tag.
    > 90 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg of the protein as determined by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Please refer to the printed manual for detailed information.
    Lyophilized from sterile PBS, pH 7.4
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
    Autre désignation
    MANF/ARMET (MANF Produits)
    ARMET Protein, ARP Protein, 3230402M22Rik Protein, AA407711 Protein, AA408789 Protein, AA673178 Protein, Armet Protein, D17914 Protein, D18Mgi17 Protein, MANF Protein, RBM15B Protein, ARP-like Protein, CG7013 Protein, DmMANF Protein, Dmel\\CG7013 Protein, anon-EST:ParkEST188 Protein, arp Protein, armet Protein, im:6909481 Protein, zgc:153327 Protein, manf Protein, mesencephalic astrocyte derived neurotrophic factor Protein, mesencephalic astrocyte-derived neurotrophic factor Protein, RNA binding motif protein 15B Protein, Mesencephalic astrocyte-derived neurotrophic factor Protein, mesencephalic astrocyte-derived neurotrophic factor S homeolog Protein, MANF Protein, Manf Protein, RBM15B Protein, manf Protein, manf.S Protein

    Background: Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF and ARMET, is a secreted protein which belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

    Synonym: 3230402M22Rik,AA407711,AA408789,AA673178,Armet,D17914,D18Mgi17

    Poids moléculaire
    19.6 kDa
    NCBI Accession
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