This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Flach, Leu, Martinisi, Skachokova, Frank, Tolnay, Stahlberg, Winkler: "Trans-seeding of Alzheimer-related tau protein by a yeast prion." dans: Alzheimer's & dementia : the journal of the Alzheimer's Association, Vol. 18, Issue 12, pp. 2481-2492, (2023) (PubMed).
Pseudonymes pour MAPT Protéines
microtubule associated protein tau (MAPT) Protéines microtubule-associated protein tau (Mapt) Protéines microtubule associated protein tau S homeolog (mapt.S) Protéines microtubule-associated protein tau (LOC5580230) Protéines microtubule-associated protein tau (CpipJ_CPIJ013260) Protéines Microtubule-associated protein tau (tau) Protéines microtubule associated protein tau (Mapt) Protéines solute carrier family 6 (neurotransmitter transporter), member 6b (slc6a6b) Protéines AI413597 Protéines AW045860 Protéines DDPAC Protéines FTDP-17 Protéines MAPT Protéines MAPTL Protéines MSTD Protéines Mtapt Protéines MTBT1 Protéines MTBT2 Protéines PHF-tau Protéines PPND Protéines pTau Protéines RNPTAU Protéines slc6a6 Protéines TAU Protéines Tau Protéines tau Protéines taut Protéines wu:fc26e12 Protéines xtp Protéines