MAPT Protein (His tag)

N° du produit ABIN7318057

Détail du produit

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MAPT protéine est marqué à la His tag.

Fonction: Recombinant Human MAPT/Tau Protein (His Tag)

Séquence: Ala2-Leu352

Attributs du produit: A DNA sequence encoding the mature form of human MAPT (NP_058525.1) (Ala2-Leu352) was expressed with a polyhistide tag at the N-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT/Tau (MAPT Produits)

Synonymes: DDPAC Protein, FTDP-17 Protein, MAPTL Protein, MSTD Protein, MTBT1 Protein, MTBT2 Protein, PPND Protein, TAU Protein, AI413597 Protein, AW045860 Protein, Mtapt Protein, Tau Protein, RNPTAU Protein, pTau Protein, tau Protein, xtp Protein, MAPT Protein, PHF-tau Protein, slc6a6 Protein, taut Protein, wu:fc26e12 Protein, microtubule associated protein tau Protein, microtubule-associated protein tau Protein, microtubule associated protein tau S homeolog Protein, Microtubule-associated protein tau Protein, solute carrier family 6 (neurotransmitter transporter), member 6b Protein, MAPT Protein, Mapt Protein, mapt.S Protein, LOC5580230 Protein, CpipJ_CPIJ013260 Protein, tau Protein, slc6a6b Protein

Sujet:

Background: MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

Synonym: DDPAC,FTDP-17,MAPT,MAPTL,MSTD,MTBT1,MTBT2,PPND,PPP1R103,TAU

Poids moléculaire: 38.7 kDa

NCBI Accession: NP_058525

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size