MDM4-binding Protein Produits
(Mdm4-binding Protein (MDM4))
Catégories
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
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Catégories MDM4-binding Protein en vedette
MDM4-binding Protein Anticorps
High quality antibodies with extensive validation data.
MDM4-binding Protein Kits ELISA
Reliable ELISA kits for a wide range of species.
MDM4-binding Protein Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MDM4-binding Protein recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IP
Validations
- (8)
N° du produit
ABIN948119
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, ICC
Validations
- (2)
- (4)
N° du produit
ABIN969282
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, IHC (p)
Validations
- (4)
N° du produit
ABIN1499354
Quantité
100 μL
Fiche technique
Fiche technique
MDM4-binding Protein recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1381305
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6951175
Quantité
96 tests
Fiche technique
Fiche technique
MDM4-binding Protein recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123869
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123868
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310604
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MDM4-binding Protein
: "MDM4 expression in fibrolamellar hepatocellular carcinoma." dans: Oncology reports, (2019) (PubMed).: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." dans: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).
: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." dans: Oncogene, (2015) (PubMed).
: "Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach." dans: Chemical biology & drug design, Vol. 86, Issue 2, pp. 180-9, (2015) (PubMed).
: "Protumorigenic role of Timeless in hepatocellular carcinoma." dans: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).
: "EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma." dans: Hepatology (Baltimore, Md.), Vol. 59, Issue 5, pp. 1886-99, (2014) (PubMed).
: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." dans: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).
: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." dans: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).
: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." dans: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).
: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." dans: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).
Synonymes et noms alternatifs relatifs à MDM4-binding Protein
MDM4, p53 regulator S homeolog (mdm4.S), MDM4, p53 regulator (MDM4), MDM4, p53 regulator (Mdm4), MDM4, p53 regulator (mdm4), transformed mouse 3T3 cell double minute 4 (Mdm4), 4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, mdmx, MDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10Protein level used designations for MDM4-binding Protein
- double minute 4 protein
- mdm2-like p53-binding protein
- p53-binding protein Mdm4
- protein Mdm4
- MDM4-related protein 1
- double minute 4, human homolog of; p53-binding protein
- protein Mdmx
- Mdm4, transformed 3T3 cell double minute 4, p53 binding protein
- double minute 4 homolog
- transformed mouse 3T3 cell double minute 4
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