MDC1 Produits
(Mdc1 (MDC1))
Catégories
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008].
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Catégories MDC1 en vedette
MDC1 Anticorps
High quality antibodies with extensive validation data.
MDC1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (2)
- (3)
N° du produit
ABIN2855454
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
N° du produit
ABIN6143659
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
N° du produit
ABIN739740
Quantité
100 μL
Fiche technique
Fiche technique
MDC1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6228688
Quantité
96 tests
Fiche technique
Fiche technique
Dernières publications sur nos produits MDC1
: "JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity." dans: Cell death and differentiation, (2019) (PubMed).: "Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks." dans: Nucleic acids research, Vol. 47, Issue 7, pp. 3467-3484, (2019) (PubMed).
: "SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression." dans: Scientific reports, Vol. 7, Issue 1, pp. 3842, (2017) (PubMed).
: "RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment." dans: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9396-410, (2016) (PubMed).
: "Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network." dans: Chromosoma, (2016) (PubMed).
: "Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites." dans: Nucleic acids research, Vol. 44, Issue 3, pp. e27, (2016) (PubMed).
: "The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex." dans: PLoS ONE, Vol. 10, Issue 12, pp. e0144957, (2015) (PubMed).
: "The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence." dans: Molecular and cellular biology, Vol. 34, Issue 10, pp. 1733-46, (2014) (PubMed).
: "DNA damage to a single chromosome end delays anaphase onset." dans: The Journal of biological chemistry, Vol. 289, Issue 33, pp. 22771-84, (2014) (PubMed).
: "Listeria monocytogenes dampens the DNA damage response." dans: PLoS pathogens, Vol. 10, Issue 10, pp. e1004470, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à MDC1
mediator of DNA damage checkpoint 1 (Mdc1), mediator of DNA damage checkpoint 1 (MDC1), mediator of DNA-damage checkpoint 1 (MDC1), 6820401C03, AA413496, mKIAA0170, Nfbd1, NFBD1Protein level used designations for MDC1
- mediation of DNA damage checkpoint 1
- mediator of DNA damage checkpoint protein 1
- homologue to Drosophila photoreceptor protein calphotin
- mediator of DNA damage checkpoint 1
- nuclear factor with BRCT domains 1
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