Melanophilin Produits
(Melanophilin (MLPH))
Catégories
This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
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Catégories Melanophilin en vedette
Melanophilin Anticorps
High quality antibodies with extensive validation data.
Melanophilin Kits ELISA
Reliable ELISA kits for a wide range of species.
Melanophilin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Melanophilin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7159304
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IF
Validations
- (3)
N° du produit
ABIN7262539
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN6263218
Quantité
100 μL
Fiche technique
Fiche technique
Melanophilin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN5592380
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6205901
Quantité
96 tests
Fiche technique
Fiche technique
Melanophilin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1311024
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3083586
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits Melanophilin
: "Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a." dans: Journal of cell science, Vol. 132, Issue 9, (2020) (PubMed).: "Identification of immunohistochemical markers for distinguishing lung adenocarcinoma from squamous cell carcinoma." dans: Journal of thoracic disease, Vol. 7, Issue 8, pp. 1398-405, (2015) (PubMed).
: "FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast." dans: PLoS ONE, Vol. 9, Issue 11, pp. e112024, (2014) (PubMed).
: "Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion." dans: The FEBS journal, Vol. 280, Issue 3, pp. 892-903, (2013) (PubMed).
: "Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes." dans: The Journal of biological chemistry, Vol. 283, Issue 34, pp. 23209-16, (2008) (PubMed).
: "A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes." dans: Molecular biology of the cell, Vol. 17, Issue 11, pp. 4720-35, (2006) (PubMed).
: "Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1215-20, (2003) (PubMed).
: "Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 18, pp. 10238-43, (2001) (PubMed).
: "jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells." dans: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 6, Issue 11, pp. 1437-46, (1996) (PubMed).
: "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport." dans: Science (New York, N.Y.), Vol. 272, Issue 5265, pp. 1161-3, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à Melanophilin
melanophilin (MLPH), melanophilin (mlph), melanophilin (Mlph), 2210418F23Rik, 5031433I09Rik, AW228792, D1Wsu84e, l(1)-3Rk, l1Rk3, ln, LOC100222096, MGC155106, Slac-2a, SLAC2-AProtein level used designations for Melanophilin
- melanophilin
- exophilin-3
- leaden protein
- slaC2-a
- slp homolog lacking C2 domains a
- synaptotagmin-like protein 2a
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